Document Detail


A study comparing a gestoden triphasic formulation with a fixed combination OC.
MedLine Citation:
PMID:  2596365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metabolic parameters were studied in 30 patients over 12 treatment cycles in a double-blind randomized comparative trial of the new progestogen gestoden in a triphasic formulation against a fixed dose combination pill containing desogrestrel, in Bandung, Indonesia. The results of this laboratory experience affirm findings in similar previous metabolic studies that: (1) the changes induced by modern low-dose pills are clinically and statistically insignificant; (2) throughout the treatment cycles, the values of the various laboratory tests remain well within the normal range; and (3) the favorable balance between coagulation and fibrinolysis is maintained. Results of lipoprotein, coagulation, fibrinolytic and liver function tests in 27 patients are presented. Gestoden's pharmacologic profile and the worldwide clinical experience with the triphasic gestoden formulation in 4285 women are discussed.
Authors:
T Agoestina; U Sabarudin; G Hoppe
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Advances in contraception : the official journal of the Society for the Advancement of Contraception     Volume:  5     ISSN:  0267-4874     ISO Abbreviation:  Adv Contracept     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607435     Medline TA:  Adv Contracept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  71-84     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Hasan Sadikin Hospital, University of Padjadgaran, Bandung, Indonesia.
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MeSH Terms
Descriptor/Qualifier:
Blood Coagulation / drug effects
Blood Pressure / drug effects
Body Weight / drug effects
Contraceptives, Oral / pharmacology*
Contraceptives, Oral, Combined / adverse effects,  pharmacology*
Contraceptives, Oral, Sequential / adverse effects,  pharmacology*
Ethinyl Estradiol / pharmacology
Female
Humans
Lipoproteins / analysis
Liver / drug effects
Liver Function Tests
Norpregnenes / pharmacology
Chemical
Reg. No./Substance:
0/Contraceptives, Oral; 0/Contraceptives, Oral, Combined; 0/Contraceptives, Oral, Sequential; 0/Lipoproteins; 0/Norpregnenes; 57-63-6/Ethinyl Estradiol; 60282-87-3/Gestodene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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