Document Detail

A study of the comparative efficacy of four common analgesics in the control of postsurgical dental pain.
MedLine Citation:
PMID:  2234874     Owner:  NLM     Status:  MEDLINE    
Four common oral analgesics were tested in a single-blind trial to determine their relative efficacy in the management of postsurgical pain in 103 patients who had their impacted third molars surgically removed under general anesthesia. The analgesics tested were acetylsalicylic acid (26 patients), ibuprofen (26 patients), a paracetamol/codeine/caffeine combination (Solpadeine) (25 patients), and dihydrocodeine (26 patients). The paracetamol/codeine/caffeine combination, ibuprofen, and acetylsalicylic acid preparations produced equally effective analgesia. Dihydrocodeine was found to be a poor analgesic in this pain model. There were no adverse reactions to any of the preparations.
S Habib; R W Matthews; C Scully; B G Levers; J P Shepherd
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, and oral pathology     Volume:  70     ISSN:  0030-4220     ISO Abbreviation:  Oral Surg. Oral Med. Oral Pathol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-18     Completed Date:  1990-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376406     Medline TA:  Oral Surg Oral Med Oral Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-63     Citation Subset:  D; IM    
Bristol Dental Hospital and School, England.
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MeSH Terms
Acetaminophen / therapeutic use
Analgesics / therapeutic use*
Analysis of Variance
Aspirin / therapeutic use
Caffeine / therapeutic use
Codeine / analogs & derivatives,  therapeutic use
Drug Combinations
Ibuprofen / therapeutic use
Molar, Third / surgery
Pain Measurement
Pain, Postoperative / drug therapy*
Random Allocation
Single-Blind Method
Tooth Extraction*
Tooth, Impacted / surgery
Reg. No./Substance:
0/Analgesics; 0/Drug Combinations; 103-90-2/Acetaminophen; 125-28-0/dihydrocodeine; 15687-27-1/Ibuprofen; 50-78-2/Aspirin; 58-08-2/Caffeine; 76-57-3/Codeine; 82400-20-2/solpadeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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