Document Detail


A study of changes in homocysteine levels during normal pregnancy and pre-eclampsia.
MedLine Citation:
PMID:  18975508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To find out changes in homocysteine levels that occur during normal pregnancy and pregnancy with pre-eclamptic toxaemia and also to find out correlation between homocysteine concentration and preeclamptic toxaemia a study was carried out among 90 women of which 30 were control which included normotensive non-pregnant women and the study group I comprised 30 pregnant normotensive women and the study group II comprised 30 pregnant women with pre-eclamptic toxaemia. Serum homocysteine was measured in all subjects using fluorescence polarisation immuno-assay. Control group had highest mean homocysteine levels while the study group I had least mean homocysteine levels (p < 0.001). Levels were significantly higher in subjects with BP > 146/100 mm Hg as compared to subjects with BP >140/90 and <146/100 mm Hg (p=0.017). There was significant difference between study group I and II at same gestational age. Hyperhomocysteinaemia was observed in pre-eclamptic females, also it was found that homocysteine levels were directly correlated with severity of pre-eclampsia.
Authors:
Urmila Singh; H P Gupta; R K Singh; Manju Shukla; Ranjana Singh; Seema Sinha Nee Mehrotra; Shweta Prasad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  106     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-11-03     Completed Date:  2008-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  India    
Other Details:
Languages:  eng     Pagination:  503-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, King George's Medical University, Lucknow.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Case-Control Studies
Cross-Sectional Studies
Female
Fluorescence Polarization
Homocysteine / blood*
Humans
Hyperhomocysteinemia / blood
Maternal Welfare*
Perinatal Care*
Pre-Eclampsia / blood*
Pregnancy
Risk Factors
Young Adult
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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