| A study of changes in homocysteine levels during normal pregnancy and pre-eclampsia. | |
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MedLine Citation:
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PMID: 18975508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To find out changes in homocysteine levels that occur during normal pregnancy and pregnancy with pre-eclamptic toxaemia and also to find out correlation between homocysteine concentration and preeclamptic toxaemia a study was carried out among 90 women of which 30 were control which included normotensive non-pregnant women and the study group I comprised 30 pregnant normotensive women and the study group II comprised 30 pregnant women with pre-eclamptic toxaemia. Serum homocysteine was measured in all subjects using fluorescence polarisation immuno-assay. Control group had highest mean homocysteine levels while the study group I had least mean homocysteine levels (p < 0.001). Levels were significantly higher in subjects with BP > 146/100 mm Hg as compared to subjects with BP >140/90 and <146/100 mm Hg (p=0.017). There was significant difference between study group I and II at same gestational age. Hyperhomocysteinaemia was observed in pre-eclamptic females, also it was found that homocysteine levels were directly correlated with severity of pre-eclampsia. |
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Authors:
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Urmila Singh; H P Gupta; R K Singh; Manju Shukla; Ranjana Singh; Seema Sinha Nee Mehrotra; Shweta Prasad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Indian Medical Association Volume: 106 ISSN: 0019-5847 ISO Abbreviation: J Indian Med Assoc Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2008-12-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505608 Medline TA: J Indian Med Assoc Country: India |
Other Details:
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Languages: eng Pagination: 503-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, King George's Medical University, Lucknow. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Cross-Sectional Studies Female Fluorescence Polarization Homocysteine / blood* Humans Hyperhomocysteinemia / blood Maternal Welfare* Perinatal Care* Pre-Eclampsia / blood* Pregnancy Risk Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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