Document Detail

A study of bispectral analysis and auditory evoked potential indices during propofol-induced hypnosis in volunteers: the effect of an episode of wakefulness on explicit and implicit memory.
MedLine Citation:
PMID:  11531678     Owner:  NLM     Status:  MEDLINE    
The bispectral index (BIS) and the auditory evoked potential (AEP) index as calculated by the new A-line monitor were measured during hypnosis with propofol, which included an episode of wakefulness. Both indices followed a similar pattern during sedation, with values decreasing with sedation and increasing when awake. Baseline AEP values varied between 60 and 98, and BIS values were between 96 and 98. The AEP-index value was at all times 10-20 points lower than the BIS-index. The transition to loss of response occurred at a mean AEP value of 46 and BIS value of 58. The transition to just responding following a period of unconsciousness occurred at a mean AEP value of 46 and BIS 65. Both monitoring techniques, however, displayed large interindividual variations making it impossible to discriminate in real time between subtle changes of clinical state. The new neurophysiological monitors A-line AEP and BIS are interesting tools for creating a better understanding of the anaesthetic effects of drugs; however, further refinements are required before their relative roles can be fully established in the clinical setting.
G Barr; R E Anderson; J G Jakobsson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  56     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  888-93     Citation Subset:  AIM; IM    
Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Anesthetics, Intravenous / pharmacology*
Consciousness / drug effects
Electroencephalography / drug effects*
Evoked Potentials, Auditory / drug effects*
Mental Recall / drug effects
Middle Aged
Monitoring, Intraoperative / methods*
Propofol / pharmacology*
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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