Document Detail


A study on the beryllium lymphocyte transformation test and the beryllium levels in working environment.
MedLine Citation:
PMID:  9248221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between airborne concentration of beryllium in the working environment and workers' beryllium lymphocyte transformation test (Be-LTT) values was examined based on data obtained from a four-year survey (1992-1995) conducted at beryllium-copper alloy manufacturing factories. This study showed that the T cells of workers continuously exposed to beryllium of more than 0.01 microgram/m3 could be activated and that the cell-mediated immune response of workers could be promoted. On the other hand, the Be-LTT of workers exposed to beryllium levels of less than 0.01 microgram/m3 was shown to be unaffected by beryllium. These findings suggest that beryllium sensitization is not manifested when level of beryllium in working environment are less than 0.01 microgram/m3. Therefore, in such cases workers do not develop Chronic beryllium disease (CBD). We concluded that the Be-LTT can be applied as a medical indicator to detect the development of CBD.
Authors:
T Yoshida; S Shima; K Nagaoka; H Taniwaki; A Wada; H Kurita; K Morita
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Industrial health     Volume:  35     ISSN:  0019-8366     ISO Abbreviation:  Ind Health     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-23     Completed Date:  1997-09-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  374-9     Citation Subset:  IM    
Affiliation:
Department of Public Health, Fujita Health University School of Medicine, Aichi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollutants, Occupational / adverse effects*
Berylliosis / diagnosis
Beryllium / adverse effects*
Chronic Disease
Environmental Monitoring
Humans
Industry
Lymphocyte Activation / drug effects*
Male
Middle Aged
Occupational Exposure / adverse effects*
Chemical
Reg. No./Substance:
0/Air Pollutants, Occupational; 7440-41-7/Beryllium
Comments/Corrections
Comment In:
Ind Health. 1998 Oct;36(4):389-91   [PMID:  9810156 ]

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