| A study on the association of serum 1,5-anhydroglucitol levels and the hyperglycemic excursions as measured by Continuous Glucose Monitoring System among Type 2 Diabetes in a Chinese Population. | |
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MedLine Citation:
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PMID: 22238204 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Blood glucose excursion is an important component of the glycemic burden, but there are no indexes that can directly reflect them. The aim was to evaluate the values and significance of serum 1,5-anhydroglucitol (1,5-AG) in Type 2 Diabetes mellitus (DM) in China, and elucidate the relationship between 1,5-AG and traditional indexes of glycemic excursions by continuous glucose monitoring system (CGMS). METHODS: A total of 576 healthy adults and 292 patients were included, and their 1,5-AG, fasting glucose (FBG) and postprandial glucose (PBG) and glycated haemoglobin (HbA1c) were measured. For 34 patients, their mean blood glucose (MBG), standard deviation of blood glucose (SDBG), mean amplitude of glucose excursion (MAGE), mean of daily differences (MODD), low blood glucose M-value index (LBMI), and the area under the curve for blood glucose above 180 mg/dl (AUC180) were calculated by CGMS. RESULTS: Serum levels of 1,5-AG among healthy adults were 28.44 ± 8.76 µg/ml with a significant gender rather than age bias. The 1,5-AG levels in T2DM were 4.57 ± 3.71 µg/ml, which were lower than those seen in the healthy adults. There was a correlation between 1,5-AG and HbA1c, FBG, PBG (r = -0.251, -0.195 and -0.349, respectively; all p < 0.05). The CGMS demonstrated that 1,5-AG presents a negative correlation with MBG, SDBG, MAGE and MODD for 7 days and with AUC180 on -3(rd) ,-4(th) and -7(th) days. CONCLUSIONS: 1,5-AG may serve as a marker of hyperglycemia and seven day hyperglycemic excursions as well as being a useful adjunct to HbA1c for diabetic blood glucose monitoring. Copyright © 2012 John Wiley & Sons, Ltd. |
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Authors:
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Y Wang; Y L Zhang; Y P Wang; C H Lei; Z L Sun |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-11 |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: - ISSN: 1520-7560 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, China. wang_yao100@163.com. |
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