| A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland. | |
| | |
MedLine Citation:
|
PMID: 9797559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To perform an exploratory analysis of the relative contribution of single MHC genes to the pathogenesis of systemic lupus erythematosus (SLE) in a homogenous white population. METHODS: MHC class II alleles and C4 allotypes were determined in 64 SLE patients and in ethnically matched controls. HLA-DR and DQ typing was performed by polymerase chain reaction amplification with sequence specific primers. C4 allotypes were determined by agarose gel electrophoresis. RESULTS: The frequency of C4A*Q0 was significantly higher in patients than in controls (46.9% v 25.3%, p = 0.002). HLA-DRB1, DQA1, and DQB1 alleles in the whole group of SLE patients were not significantly different from those of controls. On the other hand increase in DRB1*03 was observed in the group of patients with C4A*Q0, as compared with patients with other C4A allotypes (p = 0.047). There was no significant correlation between severe and mild disease, as judged by the SLEDAI, and HLADR, DQ alleles and comparing the patients with C4A*Q0 with those with other C4A allotypes there was no significant difference regarding clinical manifestations. CONCLUSION: The results are consistent with the argument that C4A deficiency contributes independently to susceptibility and the pathogenesis of SLE. C4A*Q0 in SLE patients in Iceland shows weaker linkage disequilibrium with DR3 genes than reported in most other white populations and emphasises the role of ethnicity. |
| | |
Authors:
|
K Steinsson; S Jónsdóttir; G J Arason; H Kristjánsdóttir; R Fossdal; I Skaftadóttir; A Arnason |
Related Documents
:
|
11254829 - Diaphragm strength in acute systemic lupus erythematosus in a patient with paradoxical ... 12587819 - Neuropsychiatric lupus favourable response to low dose i.v. cyclophosphamide and predni... 3134699 - Procainamide-induced lupus anticoagulant. 12625109 - Intermittent epoprostenol infusions in systemic lupus erythematosus associated pulmonar... 11708429 - Vitamin d levels in women with systemic lupus erythematosus and fibromyalgia. 3711879 - Prevalence of cognitive impairment in systemic lupus erythematosus. 8666649 - Mri of 'idiopathic' juvenile scoliosis. a prospective study. 17426909 - Apathy and verbal fluency in stn-stimulated pd patients. an observational follow-up study. 20574599 - Effect of itch, scratching and mental stress on autonomic nervous system function in at... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of the rheumatic diseases Volume: 57 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1998 Aug |
Date Detail:
|
Created Date: 1998-11-05 Completed Date: 1998-11-05 Revised Date: 2008-11-20 |
Medline Journal Info:
|
Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 503-5 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Landspítalinn, National University Hospital, Reykjavik, Iceland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Alleles* Child Complement C4 / genetics* Female Genes, MHC Class II* HLA-DQ Antigens / genetics HLA-DR Antigens / genetics Humans Iceland Lupus Erythematosus, Systemic / genetics* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Complement C4; 0/HLA-DQ Antigens; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Psychosocial risks for low back pain: are these related to work?
Next Document: Salivary and serum hyaluronic acid concentrations in patients with Sjögren's syndrome.