Document Detail


A study of adaptive responses in cell signaling in migraine and cluster headache: correlations between headache type and changes in gene expression.
MedLine Citation:
PMID:  9642493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The project was an investigation into whether changes in the expression of G-proteins underlie altered cell signaling in migraine and cluster headache. The basis for this assumption is that altered physiological responses are seen in migraineurs and that differences in cell signaling are detected biochemically in various cell types isolated from peripheral blood. Levels of three G-protein mRNAs--Gs alpha, Gi alpha, and Gq alpha, were quantified in lymphocytes from clinically well-defined migraine and cluster headache patients and correlated with headache type and influence of drug treatment. Gi alpha mRNA was reduced by 50% in all migraine patients compared with control subjects; similarly in patients with or without aura, in patients with a migraine headache at the time of sampling, and patients in a quiescent state. No reduction in the levels of Gs alpha of Gq alpha mRNA were seen in migraine patients. A smaller reduction was seen in cluster headache patients, most marked in those without medication. Levels of Gs alpha mRNA were significantly reduced in cluster headache patients compared with migraine patients. The marked down-regulation of Gi alpha mRNA in migraine, whether quiescent or acute, indicates either an adaptive response to headache in this group of patients or that low levels of Gi alpha mRNA make individuals more susceptible to migraine.
Authors:
I M Gardiner; F Ahmed; T J Steiner; A McBain; C Kennard; J de Belleroche
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  18     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-31     Completed Date:  1998-08-31     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  192-6     Citation Subset:  IM    
Affiliation:
Division of Neurosciences, Imperial College School of Medicine at Charing Cross Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cluster Headache / genetics*
Down-Regulation / genetics
Female
GTP-Binding Protein alpha Subunits, Gi-Go / physiology
GTP-Binding Protein alpha Subunits, Gs / physiology
GTP-Binding Proteins / genetics*
Gene Expression / physiology
Humans
Lymphocytes / metabolism
Male
Middle Aged
Migraine Disorders / genetics*
Phosphatidylinositol Phosphates / metabolism
RNA, Messenger / genetics*
Signal Transduction / genetics*
Chemical
Reg. No./Substance:
0/Phosphatidylinositol Phosphates; 0/RNA, Messenger; EC 3.6.1.-/GTP-Binding Proteins; EC 3.6.5.1/GTP-Binding Protein alpha Subunits, Gi-Go; EC 3.6.5.1/GTP-Binding Protein alpha Subunits, Gs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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