Document Detail

A study of P300 in melancholic depression--correlation with psychotic features.
MedLine Citation:
PMID:  8018798     Owner:  NLM     Status:  MEDLINE    
The relationship between delusions and hallucinations (psychotic features) in melancholic depression and auditory P300 was studied. Forty patients with melancholic depression as per DSM-III-R were studied, 20 of whom had hallucinations and/or delusions. The 20 patients of the two groups were individually matched on age, gender, sociodemographic variables, and psychopathology (except for psychotic features). Auditory P300 obtained by the "oddball paradigm" showed that those with hallucinations and/or delusions had a significantly smaller P3 amplitude. Significant correlations between "psychotic features" and P3 amplitude was found. Implications of these findings on research, classification, and management of depression have been outlined.
P J Santosh; S Malhotra; M Raghunathan; Y N Mehra
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  35     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-04     Completed Date:  1994-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  474-9     Citation Subset:  IM    
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Acoustic Stimulation
Biological Markers
Delusions / diagnosis*,  physiopathology
Depressive Disorder / classification,  diagnosis*,  physiopathology
Diagnosis, Differential
Evoked Potentials, Auditory / physiology*
Hallucinations / diagnosis*,  physiopathology
Middle Aged
Psychiatric Status Rating Scales
Reg. No./Substance:
0/Biological Markers

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