Document Detail


A study on Huntington's disease associated trinucleotide repeat within the Chinese population.
MedLine Citation:
PMID:  7480359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Analysis of the polymorphic (CAG)n repeat in the huntingtin gene within the Chinese population in Taiwan confirmed the presence of an expanded repeat on all Huntington's disease (HD) chromosomes. Measurement of the specific CAG repeat sequence in 35 HD chromosomes from 11 unrelated families and 159 control chromosomes showed a range of from 9 to 29 (with a median of 17) repeats in normal subjects and 40 to 58 (with a median of 44) in affected subjects. The size distributions of normal and affected alleles did not overlap. The change in the size of the repeat in the HD size range on transmission for both sexes was variable. The expansion size inversely correlated with age at the onset in HD, especially from the early-onset disease. In summary, the molecular biology of HD is indistinguishable in Chinese and Caucasian populations, but the idea that world-wide HD evolved from a very limited number of European founders is no longer tenable.
Authors:
B W Soong; J T Wang
Related Documents :
3019869 - Repeated dna sequences in the distal long arm of the human x chromosome.
16507999 - Condensin loaded onto the replication fork barrier site in the rrna gene repeats during...
18285829 - Pathogenic expansions of the sca6 locus are associated with a common cacna1a haplotype ...
7759089 - Characterisation of three microsatellite polymorphisms (d21s1262, d21s1419 and d21s1421...
8921379 - Physical and genetic mapping of novel microsatellite polymorphisms on human chromosome 19.
12691979 - Genome-wide analysis of bkm sequences (gata repeats): predominant association with sex ...
9670899 - Replication analysis of a putative susceptibility locus (egi) for idiopathic generalize...
17705059 - Molecular cytogenetics and characterization of a zz/zw sex chromosome system in triport...
21775299 - The ability of the mouse lymphoma tk assay to detect aneugens.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Science Council, Republic of China. Part B, Life sciences     Volume:  19     ISSN:  0255-6596     ISO Abbreviation:  Proc. Natl. Sci. Counc. Repub. China B     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-12-07     Completed Date:  1995-12-07     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  8502426     Medline TA:  Proc Natl Sci Counc Repub China B     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Affiliation:
Department of Neurology, Veterans General Hospital-Taipei, Taipei, Taiwan, R.O.C.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Factors
Alleles
Base Sequence
Female
Heterozygote
Humans
Huntington Disease / genetics*
Male
Molecular Sequence Data
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid*
Taiwan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ethanol and acetaldehyde metabolism in chinese with different aldehyde dehydrogenase-2 genotypes.
Next Document:  Effects of ascites and body position on gas exchange in patients with cirrhosis.