Document Detail

The structure of tight junctions in the tracheal epithelium may not correlate with permeability.
MedLine Citation:
PMID:  6713489     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that cigarette smoke produces changes in the morphology of tight junctions guinea pigs were exposed to cigarette smoke or air in a previously standardized fashion (Simani et al. 1974). Permeability is greatest one half hour following exposure to cigarette smoke (Hulbert et al. 1981). The animals were sacrificed at that time. The tracheal epithelium was studied using both thin-section and freeze-fracture techniques. A quantitative analysis of the organization and integrity of junctional complexes was performed for each animal. Organization was assessed by measuring and comparing areas delimited by PF fibers and EF furrows. PF fiber integrity was assessed by measuring uninterrupted lengths of fibers and furrows from freeze-fracture replicas. This assessment did not demonstrate a change in tight-junction morphology following exposure to cigarette smoke.
D C Walker; A MacKenzie; B R Wiggs; W C Hulbert; J C Hogg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell and tissue research     Volume:  235     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1984  
Date Detail:
Created Date:  1984-06-18     Completed Date:  1984-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  607-13     Citation Subset:  IM    
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MeSH Terms
Cell Membrane Permeability
Epithelial Cells
Epithelium / physiology
Freeze Fracturing
Guinea Pigs
Intercellular Junctions*
Trachea / anatomy & histology*,  physiology

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