| The structure and function of the pulmonary vasculature in mild chronic obstructive pulmonary disease. The effect of oxygen and exercise. | |
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MedLine Citation:
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PMID: 6625346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The structure and function of the pulmonary circulation was investigated in 17 patients requiring pulmonary resection. All 17 performed pulmonary function tests and 13 underwent right heart catheterization preoperatively. The surgical specimens of the lung were analyzed with respect to the severity of the emphysema, the severity of the airways disease, and the hypertensive changes in the small pulmonary arteries and arterioles. The data show that pulmonary artery (Ppa) and pulmonary artery wedge (Ppaw) pressures and cardiac output were normal at rest. However, patients with more severe disease showed greater increases in Ppa and Ppaw with exercise than did patients with minimal or no disease. Oxygen breathing had no effect at rest but lowered Ppa and Ppaw during exercise in the patients with more severe disease. Histologic studies showed that greater degrees of emphysema and small airways disease were associated with hypertensive changes in the pulmonary vasculature. We conclude that patients with moderate obstructive lung disease have elevated pulmonary vascular pressures during exercise and structural changes in the pulmonary arteries consistent with pulmonary hypertension when compared with patients with minimal or no disease. Although there are several possible explanations for the increased vascular pressures seen with exercise, we favor gas trapping leading to increased alveolar and pleural pressures, with oxygen breathing preventing this response by shortening the time constants of the peripheral lung units. |
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Authors:
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J L Wright; L Lawson; P D Paré; R O Hooper; D I Peretz; J M Nelems; M Schulzer; J C Hogg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American review of respiratory disease Volume: 128 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 702-7 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Output Female Hemodynamics Humans Hypertension, Pulmonary / complications*, etiology Lung / blood supply*, pathology, physiopathology Lung Diseases, Obstructive / complications, physiopathology* Male Middle Aged Oxygen Inhalation Therapy* Physical Exertion* Pulmonary Emphysema / complications, physiopathology Respiratory Function Tests Smoking |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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