| The structure of brevistin. Studies on antibiotics from the genus Bacillus. X. | |
| | |
MedLine Citation:
|
PMID: 931806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acid hydrolysis revealed the constituent amino acids by brevistin as follows: aspartic acid (D-form 2, L-form 1), L-threonine (1), glycine (1), sum of L-valine and L-isoleucine (1), L-phenylalanine (1), L-trytophan (1), and 2,4-diaminobutyric acid (D-form 1, L-form 1). The constituent fatty acid was elucidated to be anteisononanoic acid by gas chromatography-mass spectrometry. A lactone linkage was proved between phenylalanine and the hydroxy group of threonine. Opening the lactone ring with dilute alkali afforded brevistinic acid. Deacylation with an enzyme preparation, Polymyxin Acylase, gave deacyl brevistinic acid. Cleavage reaction with N-bromosuccinimide, sequential analysis by EDMAN degradation and some additional evidences clarified the total structure of brevistin. |
| | |
Authors:
|
J Shoji; T Kato |
Related Documents
:
|
7797436 - Akd-2a, b, c and d, new antibiotics from streptomyces sp. ocu-42815. taxonomy, fermenta... 17721006 - Isolation and absolute configuration of smtp-0, a simplest congener of the smtp family ... 2963756 - Teicoplanin: chemical, physico-chemical and biological aspects. 11114036 - Molecular characterization of a highly heterogeneous mixture of glucosylceramides from ... 21324226 - The skinny on tuna fat: health implications. 12037326 - The nucleic acid database. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of antibiotics Volume: 29 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 1976 Apr |
Date Detail:
|
Created Date: 1976-09-01 Completed Date: 1976-09-01 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 380-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetic Acids Acylation Amino Acids / analysis, isolation & purification Anti-Bacterial Agents / analysis* Bacillus / metabolism Borohydrides Bromosuccinimide Chemical Phenomena Chemistry Circular Dichroism Fatty Acids / analysis Hydrolysis Oxidation-Reduction Peptides, Cyclic / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Acetic Acids; 0/Amino Acids; 0/Anti-Bacterial Agents; 0/Borohydrides; 0/Fatty Acids; 0/Peptides, Cyclic; 39660-53-2/Bromosuccinimide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolation of brevistin, a new peptide antibiotic. Studies on antibiotics from the genus Bacillus. IX...
Next Document: Isolation of a new antibiotic, laterosporamine. Studies on antibiotics from the genus Bacillus. XIII...