Document Detail

The structure of brevistin. Studies on antibiotics from the genus Bacillus. X.
MedLine Citation:
PMID:  931806     Owner:  NLM     Status:  MEDLINE    
Acid hydrolysis revealed the constituent amino acids by brevistin as follows: aspartic acid (D-form 2, L-form 1), L-threonine (1), glycine (1), sum of L-valine and L-isoleucine (1), L-phenylalanine (1), L-trytophan (1), and 2,4-diaminobutyric acid (D-form 1, L-form 1). The constituent fatty acid was elucidated to be anteisononanoic acid by gas chromatography-mass spectrometry. A lactone linkage was proved between phenylalanine and the hydroxy group of threonine. Opening the lactone ring with dilute alkali afforded brevistinic acid. Deacylation with an enzyme preparation, Polymyxin Acylase, gave deacyl brevistinic acid. Cleavage reaction with N-bromosuccinimide, sequential analysis by EDMAN degradation and some additional evidences clarified the total structure of brevistin.
J Shoji; T Kato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  29     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  380-9     Citation Subset:  IM    
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MeSH Terms
Acetic Acids
Amino Acids / analysis,  isolation & purification
Anti-Bacterial Agents / analysis*
Bacillus / metabolism
Chemical Phenomena
Circular Dichroism
Fatty Acids / analysis
Peptides, Cyclic / analysis
Reg. No./Substance:
0/Acetic Acids; 0/Amino Acids; 0/Anti-Bacterial Agents; 0/Borohydrides; 0/Fatty Acids; 0/Peptides, Cyclic; 39660-53-2/Bromosuccinimide

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