Document Detail

A structural model for the interaction of haem with unsaturated fatty acids explaining its quasi-lipoxygenase activity. Quantum chemical calculations.
MedLine Citation:
PMID:  6426479     Owner:  NLM     Status:  MEDLINE    
The quasi-lipoxygenase activity of haemoglobin differs in many respects from the well-known haemin-catalyzed lipid peroxidation (1-4), especially in its high substrate specificity for unsaturated fatty acids containing one 1,4-pentadiene system (dienoic fatty acids). In this report a structural model for the fatty acid haem interaction based on quantum-chemical calculations is presented which show that only dienoic fatty acids are bound to the haem in such a way that the initial hydrogen abstraction that is necessary for the over-all reaction, is favoured sterically and energetically.
H Kühn; A Hache; H Sklenar; T Schewe; S M Rapoport
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  42     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1983  
Date Detail:
Created Date:  1984-06-06     Completed Date:  1984-06-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  S175-6     Citation Subset:  IM    
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MeSH Terms
Chemical Phenomena
Fatty Acids, Unsaturated*
Hemoglobins / metabolism
Lipoxygenase / metabolism*
Models, Molecular
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Hemoglobins; 14875-96-8/Heme; EC

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