Document Detail


A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties.
MedLine Citation:
PMID:  23311367     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The vascular endothelial growth factor (VEGF) is known as one of the main promoter of angiogenesis - the process of blood vessel formation. Angiogenesis has been recognized as a key stage for cancer development and metastasis. In this paper, we propose a structural model of the main molecular pathways involved in the endothelial cells response to VEGF stimuli. The model, built on qualitative information from knowledge databases, is composed of 38 ordinary differential equations with 78 parameters and focuses on the signalling driving endothelial cell proliferation, migration and resistance to apoptosis. Following a VEGF stimulus, the model predicts an increase of proliferation and migration capability, and a decrease in the apoptosis activity. Model simulations and sensitivity analysis highlight the emergence of robustness and redundancy properties of the pathway. If further calibrated and validated, this model could serve as tool to analyse and formulate new hypothesis on th e VEGF signalling cascade and its role in cancer development and treatment.
Authors:
Floriane Lignet; Vincent Calvez; Emmanuel Grenier; Benjamin Ribba
Related Documents :
24838247 - Intermolecular transmembrane domain interactions activate integrin αiibβ3.
24210817 - Sharpin regulates uropod detachment in migrating lymphocytes.
16147977 - Mt1-matrix metalloproteinase directs arterial wall invasion and neointima formation by ...
6094597 - The effect of the extracellular matrix on the detachment of human endothelial cells.
18065657 - Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculoge...
19824877 - Fibroblast growth factor-2 and vascular endothelial growth factor expression in the ile...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mathematical biosciences and engineering : MBE     Volume:  10     ISSN:  1551-0018     ISO Abbreviation:  Math Biosci Eng     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197794     Medline TA:  Math Biosci Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  167-84     Citation Subset:  IM    
Affiliation:
INRIA, Project-team NUMED, Ecole Normale Superieure de Lyon, 46 allee d'Italie, 69007 Lyon Cedex 07, France. benjamin.ribba@inria.fr.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  On optimal and suboptimal treatment strategies for a mathematical model of leukemia.
Next Document:  A therapy inactivating the tumor angiogenic factors.