Document Detail

The structural gene for transferrin (TF) maps to 3q21----3qter.
MedLine Citation:
PMID:  6326658     Owner:  NLM     Status:  MEDLINE    
A cloned human cDNA for transferrin (TF) was used as hybridization probe in analysing a series of rodent x human somatic cell hybrids for the presence of human TF sequences. The assignment to chromosome 3 was further refined to region 3q21----3qter using hybrids that carried a translocated chromosome 3 and fibroblasts from a patient trisomic for this region. The gene for TF therefore maps to the same region as the gene for transferrin receptor (TFR) thereby defining an iron transport region on 3q2 to which the transferrin-related tumor associated antigen p97 may also belong. It follows that the genes for pseudocholinesterase (CHE1), ceruleoplasmin (CP) and alpha-2HS-glycoprotein (A2HS) which belong to the, as yet unassigned, linkage group of TF, now also map to chromosome 3 in man.
C Huerre; G Uzan; K H Grzeschik; D Weil; M Levin; M C Hors-Cayla; J Boué; A Kahn; C Junien
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annales de génétique     Volume:  27     ISSN:  0003-3995     ISO Abbreviation:  Ann. Genet.     Publication Date:  1984  
Date Detail:
Created Date:  1984-06-12     Completed Date:  1984-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370562     Medline TA:  Ann Genet     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
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MeSH Terms
Chromosome Mapping
Chromosomes, Human, 1-3 / ultrastructure*
DNA / genetics
Fibroblasts / ultrastructure
Hybrid Cells / ultrastructure
Receptors, Cell Surface / genetics
Receptors, Transferrin
Transferrin / genetics*
Reg. No./Substance:
0/Receptors, Cell Surface; 0/Receptors, Transferrin; 11096-37-0/Transferrin; 9007-49-2/DNA

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