Document Detail

The structural gene coding for thiamin-repressible acid phosphatase in Schizosaccharomyces pombe.
MedLine Citation:
PMID:  2249257     Owner:  NLM     Status:  MEDLINE    
The pho4 gene of the fission yeast Schizosaccharomyces pombe is regulated by thiamin. The nucleotide sequence of this gene is given here and it is shown that it matches the amino acid sequence of thiamin-repressible acid phosphatase, corroborating genetic evidence that pho4 represents the structural gene of this enzyme. The gene codes for a protein of 463 amino acids in length and shows regions of strong similarity with the phosphate-repressible acid phosphatase of Schizosaccharomyces pombe. The enzyme has a cleavable signal sequence 18 amino acids long and carries nine potential N-glycosylation sites.
J W Yang; M E Schweingruber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current genetics     Volume:  18     ISSN:  0172-8083     ISO Abbreviation:  Curr. Genet.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-01-14     Completed Date:  1991-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004904     Medline TA:  Curr Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  IM    
Institute of General Microbiology, University of Bern, Switzerland.
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MeSH Terms
Acid Phosphatase / antagonists & inhibitors,  genetics*
Amino Acid Sequence
Base Sequence
Cloning, Molecular
Genes, Fungal*
Molecular Sequence Data
Restriction Mapping
Schizosaccharomyces / genetics*
Sequence Homology, Nucleic Acid
Thiamine / pharmacology*
Reg. No./Substance:
59-43-8/Thiamine; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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