Document Detail

A structural basis for food allergy: the role of cross-reactivity.
MedLine Citation:
PMID:  18188023     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Immunologic cross-reactivity, which is important in many aspects of host defense and immune-mediated diseases, is a prominent feature of allergic disorders. The goal of this article is to define allergenic cross-reactivity and its role in food allergy, review current understanding of mechanisms of cross-reactivity, and consider how advances in our ability to predict cross-reactivity can impact diagnosis and treatment of food allergy. RECENT FINDINGS: Recent evidence suggests that specific T cells, in addition to IgE, developed in response to inhaled allergens can cross-react with related food allergens, leading to distinct clinical reactions. Several new cross-reactivities have been identified, including food-food, pollen-food, and latex-venom associations. Debate continues regarding prediction of allergenicity based on protein structure, and clinical relevance of in-vitro testing. Cross-reactivity is also being used to develop specific immunotherapy for treatment of food allergy. SUMMARY: A thorough understanding of immunologic cross-reactivity is essential to advancing our knowledge about food allergy. This knowledge will help elucidate the pathogenesis of the disorder and prevent exposures to allergenic, genetically engineered foods. New insight will allow for better utilization of current diagnostic tools and the development of more accurate tests and therapies for food allergy.
Rana S Bonds; Terumi Midoro-Horiuti; Randall Goldblum
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  8     ISSN:  1528-4050     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-11     Completed Date:  2008-05-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-6     Citation Subset:  IM    
Division of Allergy, Pulmonary, Immunology, Critical Care and Sleep, University of Texas Medical Branch, Galveston, Texas 77555, USA.
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MeSH Terms
Allergens* / chemistry,  immunology
Antigens, Plant / chemistry,  immunology
Binding Sites, Antibody
Carbohydrates / immunology
Carrier Proteins / chemistry,  immunology
Cross Reactions
Epitopes / chemistry,  immunology
False Positive Reactions
Food Hypersensitivity / immunology*
Immunoglobulin E / immunology
Molecular Mimicry*
Plant Proteins / chemistry,  immunology
Profilins / chemistry,  immunology
Structural Homology, Protein*
Reg. No./Substance:
0/Allergens; 0/Antigens, Plant; 0/Binding Sites, Antibody; 0/Carbohydrates; 0/Carrier Proteins; 0/Epitopes; 0/Plant Proteins; 0/Profilins; 0/lipid transfer proteins, plant; 37341-29-0/Immunoglobulin E

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