Document Detail

A strength exercise program in rats with epilepsy is protective against seizures.
MedLine Citation:
PMID:  23103304     Owner:  NLM     Status:  Publisher    
The beneficial effects of physical exercise on epilepsy, such as a decreased seizure frequency, have been observed following aerobic exercise programs in both clinical and experimental studies. However, it is not well clarified whether other types of exercise, including strength exercise, can provide similar benefits for epilepsy. Forty four animals with epilepsy were continuously monitored 24h a day for 60days and divided into two periods of 30days. The first period was used to determine the number of seizures before beginning the physical exercise program, and the second period was utilized to determine the number of seizures during the strength training. The mean frequency of seizures in the control and SHAM groups increased significantly from period 1 to period 2. Although the frequency of seizures did not change significantly between the two periods of 30days of observation in the strength exercise group, a significant reduction in the seizure frequency was observed compared with the control and SHAM groups in period 2. Our study demonstrated that a strength exercise program exerted a significant influence on the seizure frequency in animals with epilepsy and strengthens the observed beneficial effect of exercise on epilepsy that has been demonstrated in animal studies. The finding of this nonclinical study can open a new window to verify the beneficial contribution of strength exercise in epilepsy. Further experimental and clinical investigations are necessary to explore the extent to which strength exercise interferes with the epileptic condition.
Luiz Fernando Peixinho-Pena; Jansen Fernandes; Alexandre Aparecido de Almeida; Fabiano Guimarães Novaes Gomes; Ricardo Cassilhas; Daniel Paulino Venancio; Marco Tulio de Mello; Fulvio Alexandre Scorza; Esper Abrão Cavalheiro; Ricardo Mario Arida
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-23
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  25     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  323-328     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Departamento de Fisiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil.
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