Document Detail

A strategy to enhance the wettability of bioacive paper-based sensors.
MedLine Citation:
PMID:  23151066     Owner:  NLM     Status:  Publisher    
This paper reports a potential method that can restore the wettability of bioactive paper-based sensors while maintaining their bioactivity. This study is driven by the need to increase the wettability of the antibody-loaded blood typing paper devices in order to increase the blood typing assaying speed using such paper devices. Plasma treatment is used to improve the wettability of bioactive paper; the protective effect of bovine serum albumin (BSA) to biomolecules against plasma deactivation is investigated. In the first stage, horseraddish peroxidase (HRP) was used as a model biomolecule, because of the convenience of its quantifiable colorimetric reaction with a substrate. By using this protection approach, the inactivation of biomolecules on paper during the plasma treatment is significantly slowed down. This approach enables plasma treatment to be used for fabricating paper-based bioactive sensors to achieve strong wettability for rapid penetration of liquid samples or reagents. Finally, we demonstrate the use of plasma treatment to increase the wettability of antibody treated blood typing paper. After the treatment, the blood typing paper becomes highly wettable; it allows much faster penetration of blood samples into the plasma treated testing paper. Antibodies on the paper are still sufficiently active for blood typing and can report patients' blood type accurately.
Junfei Tian; Purim Jarujamrus; Lizi Li; Miaosi Li; Wei Shen
Related Documents :
20505536 - Schistocytic hemolytic anemia owing to central venous catheter in a child with acute ly...
23714376 - Blood conservation devices in critical care: a narrative review.
22124776 - Chronic cerebrospinal venous insufficiency: does ultrasound really distinguish multiple...
11711806 - Assessing the adequacy of peripherally inserted central catheters for power injection o...
22870156 - Innovative approach for prevention and treatment of post subarachnoid hemorrhage vasosp...
8672736 - A comparison of doppler flowmetry with conventional assessment of acute changes in hepa...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  ACS applied materials & interfaces     Volume:  -     ISSN:  1944-8252     ISO Abbreviation:  ACS Appl Mater Interfaces     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504991     Medline TA:  ACS Appl Mater Interfaces     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Microscopic Rates of Peptide-Phospholipid Bilayer Interactions from Single-Molecule Residence Times.
Next Document:  Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood...