| A strategy to decrease partial scan reconstruction artifacts in myocardial perfusion CT: Phantom and in vivo evaluation. | |
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MedLine Citation:
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PMID: 22225290 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: Partial scan reconstruction (PSR) artifacts are present in myocardial perfusion imaging using dynamic multidetector computed tomography (MDCT). PSR artifacts appear as temporal CT number variations due to inconsistencies in the angular data range used to reconstruct images and compromise the quantitative value of myocardial perfusion when using MDCT. The purpose of this work is to present and evaluate a technique termed targeted spatial frequency filtration (TSFF) to reduce CT number variations due to PSR when applied to myocardial perfusion imaging using MDCT.Methods: The TSFF algorithm requires acquiring enough X-ray projections to reconstruct both partial (π + fan angle α) and full (2π) scans. Then, using spatial linear filters, the TSFF-corrected image data are created by superimposing the low spatial frequency content of the full scan reconstruction (containing no PSR artifacts, but having low spatial resolution and worse temporal resolution) with the high spatial frequency content of the partial scan reconstruction (containing high spatial frequencies and better temporal resolution). The TSFF method was evaluated both in a static anthropomorphic thoracic phantom and using an in vivo porcine model and compared with a previously validated reference standard technique that avoids PSR artifacts by pacing the animal heart in synchrony with the gantry rotation. CT number variations were quantified by measuring the range and standard deviation of CT numbers in selected regions of interest (ROIs) over time. Myocardial perfusion parameters such as blood volume (BV), mean transit time (MTT), and blood flow (BF) were quantified and compared in the in vivo study.Results: Phantom experiments demonstrated that TSFF reduced PSR artifacts by as much as tenfold, depending on the location of the ROI. For the in vivo experiments, the TSFF-corrected data showed two- to threefold decrease in CT number variations. Also, after TSFF, the perfusion parameters had an average difference of 13.1% (range 4.5%-25.6%) relative to the reference method, in contrast to an average difference of 31.8% (range 0.3%-54.0%) between the non-TSFF processed data with the reference method.Conclusions: TSFF demonstrated consistent reduction in CT number variations due to PSR using controlled phantom and in vivo experiments. TSFF-corrected data provided quantitative measures of perfusion (BV, MTT, and BF) with better agreement to a reference method compared to noncorrected data. Practical implementation of TSFF is expected to incur in an additional radiation exposure of 14%, when tube current is modulated to 20% of its maximum, to complete the needed full scan reconstruction. |
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Authors:
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Juan C Ramirez-Giraldo; Lifeng Yu; Birgit Kantor; Erik L Ritman; Cynthia H McCollough |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical physics Volume: 39 ISSN: 0094-2405 ISO Abbreviation: Med Phys Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425746 Medline TA: Med Phys Country: United States |
Other Details:
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Languages: eng Pagination: 214 Citation Subset: IM |
Affiliation:
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Department of Radiology, CT Clinical Innovation Center, Mayo Clinic College of Medicine, Rochester, Minnesota 55905 and Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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