Document Detail


A strategy for detecting optimal ratio of cardioprotection-dependent three compounds as quality control of Guan-Xin-Er-Hao formula.
MedLine Citation:
PMID:  21073938     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIMS: We aimed to detect optimal ratio of cardioprotection-dependent absorbed bioactive compounds (ABCs) as quality control of Guan-Xin-Er-Hao (GXEH) formula extracted by various processings.
METHODS: Ferulic acid (F), tanshinol (T), hydroxysafflor yellow A (A), protocatechualdehyde (P) and paeoniflorin (E) in GXEH formula and FTA in blood from rat with acute myocardial infarction (AMI) were first identified by HPLC-MS/MS, and FTAPE in GXEH formulae with various herbs, extraction times and extraction water volumes were then quantitated only by HPLC.
RESULTS: FTAPE in various GXEH were determined. FTA were selected as GXEH's ABCs. Ratios of FTA were determined, suggesting the high (1:6.1:15.6), medium (1:1.7:15.2) and low (1:0.2:15.3) ratios. Three FTA ratios and their parent formulae ratio-dependently reduced infarct size, myocardial apoptosis and caspase-3 activity.
CONCLUSION: There is the optimal ratio of F:T:A among various formulae, contributing to the best cardioprotection. This FTA ratio was developed as quality control of GXEH formula.
Authors:
Yang Wang; Xi Huang; Feng Qin; Ping Ren; Zhengyan Zhu; Rong Fan; Chunhu Zhang; Hainan Zhang; Tao Tang; Juan He; Zhaoqian Liu; Honghao Zhou
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Publication Detail:
Type:  Journal Article     Date:  2010-11-10
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  133     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  735-42     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2010. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Key Laboratory of Traditional Chinese Medicine Gan Organ of SATCM, Xiangya Hospital, Central South University, Changsha 410008, China.
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