| A strategy for the contrast enhancement of malignant tumors using dynamic computed tomography and intravascular pharmacokinetics. | |
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MedLine Citation:
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PMID: 7422835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sequential dynamic computed tomographic (CT) body scans were performed during administration of diatrizoate (intravascular bolus and infusion) in 18 cancer patients, three patients with cysts, and four rabbits with V2 carcinoma. The best diagnostic images occurred soon after the bolus was given (within 60--90 sec.). Tumors and normal tissue became isodense with drip infusions and on delayed scans. Tumors had increased CT numbers (mean, 29.2; range, 11--64); unchanging CT numbers helped identify cysts. Three cancer patients were scanned after both intravenous and intra-arterial injection of contrast media. Contrast enhancement and cancer CT numbers were highest after intra-arterial administration. |
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Authors:
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S W Young; R J Turner; R A Castellino |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Radiology Volume: 137 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1980 Oct |
Date Detail:
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Created Date: 1980-12-18 Completed Date: 1980-12-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-47 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Neoplasms
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radiography Animals Cysts / radiography Diatrizoate / diagnostic use* Humans Kinetics Liver Neoplasms / radiography Neoplasm Metastasis Neoplasms / radiography* Neoplasms, Experimental / radiography Radiographic Image Enhancement / methods* Thoracic Neoplasms / radiography Tomography, X-Ray Computed / methods* |
| Grant Support | |
ID/Acronym/Agency:
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CA-05838/CA/NCI NIH HHS; CA-24879/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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117-96-4/Diatrizoate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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