Document Detail


The storage quality of apheresis platelets--analysis of results from seven different cell separators.
MedLine Citation:
PMID:  10168554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apheresis platelet concentrates (CAP) have been available for more than 20 years. Now, as a result of the use of, and progress in, automatic blood separation techniques, the quality of platelets is continually being improved so that we currently have access to purified concentrates which are not contaminated by red cells and contain only very few white cells. In view of the wide experience available to us, it was useful to monitor a number of qualitative parameters indicating platelet activation during storage. We monitored platelet aggregation, release of beta thromboglobulin, activation of complement and other basic parameters in seven platelet concentrates from seven cell separators (Cobe Spectra, MCS Haemonetics, CS3000+, Baxter, Excel Dideco, Autopheresis C Baxter, and V50 Haemonetics). We found that in the majority of cases aggregation was greatly reduced during storage. Release of beta thromboglobulin and activation of complement increased. pH remained within acceptable limits in some cases. However, in others (MCS, Excel), a decrease in pH < 6.0 was found. To conclude, although CAP, which are from a single donor, reduce the risks of transfusion, they are not protected from physical alteration and therefore from reduction in the clinical effects of transfusion. It is therefore necessary to improve the storage conditions of these cells in the future, for example by designing new plastics, or adding platelet storage media. Basic biological parameters should also be defined, within the framework of quality assurance, to evaluate platelet quality.
Authors:
F Schooneman; C Claise
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion science     Volume:  17     ISSN:  0955-3886     ISO Abbreviation:  Transfus Sci     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-08-19     Completed Date:  1997-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9001514     Medline TA:  Transfus Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  559-74     Citation Subset:  T    
Affiliation:
Blòod Transfusion Centre, Vandoeuvre les Nancy, France.
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MeSH Terms
Descriptor/Qualifier:
Blood Preservation*
Humans
Platelet Transfusion*
Plateletpheresis / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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