Document Detail

The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF.
MedLine Citation:
PMID:  1996989     Owner:  NLM     Status:  MEDLINE    
The migration of arterial smooth muscle cells from the media to the intima is a crucial event for the development of the atherosclerotic lesion, and platelet derived growth factor (PDGF) is thought to play an important role in this process. Here we report that the spontaneous migration of bovine smooth muscle (BSM) cells is dependent on endogenously produced basic fibroblast growth factor (bFGF). PDGF stimulates the migration of BSM cells and its effect is abolished by affinity purified anti-bFGF antibody. PDGF induces bFGF mRNA in BSM cells. These results indicate that the effect of PDGF on the migration of BSM cells may be mediated by the induction of endogenous bFGF.
Y Sato; R Hamanaka; J Ono; M Kuwano; D B Rifkin; R Takaki
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  174     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-27     Completed Date:  1991-03-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1260-6     Citation Subset:  IM    
First Department of Medicine, Medical College of Oita, Japan.
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MeSH Terms
Aorta / drug effects,  physiology
Blotting, Northern
Cell Movement / drug effects
Cells, Cultured
DNA Probes
Fibroblast Growth Factor 2 / genetics*,  immunology
Muscle, Smooth, Vascular / drug effects,  physiology*
Platelet-Derived Growth Factor / pharmacology*
RNA, Messenger / analysis,  genetics
Grant Support
Reg. No./Substance:
0/Antibodies; 0/DNA Probes; 0/Platelet-Derived Growth Factor; 0/RNA, Messenger; 103107-01-3/Fibroblast Growth Factor 2

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