| The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF. | |
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MedLine Citation:
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PMID: 1996989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The migration of arterial smooth muscle cells from the media to the intima is a crucial event for the development of the atherosclerotic lesion, and platelet derived growth factor (PDGF) is thought to play an important role in this process. Here we report that the spontaneous migration of bovine smooth muscle (BSM) cells is dependent on endogenously produced basic fibroblast growth factor (bFGF). PDGF stimulates the migration of BSM cells and its effect is abolished by affinity purified anti-bFGF antibody. PDGF induces bFGF mRNA in BSM cells. These results indicate that the effect of PDGF on the migration of BSM cells may be mediated by the induction of endogenous bFGF. |
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Authors:
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Y Sato; R Hamanaka; J Ono; M Kuwano; D B Rifkin; R Takaki |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 174 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-27 Completed Date: 1991-03-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1260-6 Citation Subset: IM |
Affiliation:
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First Department of Medicine, Medical College of Oita, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies Aorta / drug effects, physiology Blotting, Northern Cattle Cell Movement / drug effects Cells, Cultured DNA Probes Fibroblast Growth Factor 2 / genetics*, immunology Humans Kinetics Muscle, Smooth, Vascular / drug effects, physiology* Platelet-Derived Growth Factor / pharmacology* RNA, Messenger / analysis, genetics |
| Grant Support | |
ID/Acronym/Agency:
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CA34282/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/DNA Probes; 0/Platelet-Derived Growth Factor; 0/RNA, Messenger; 103107-01-3/Fibroblast Growth Factor 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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