Document Detail

The stimulation of glucose absorption and metabolism in rat jejunum by bradykinin: dependence on the composition of commercial diets.
MedLine Citation:
PMID:  2752034     Owner:  NLM     Status:  MEDLINE    
Rats were maintained on one of two standard commercial chow diets, Oxoid modified 41B or Bantin & Kingman rat and mouse diet, which differ in that linoleic acid comprises 27% and 44% of their total fatty acid content, respectively: the effects of bradykinin on the absorption, transmural transport and metabolism of glucose (5 mM) were then measured by the perfusion of isolated jejunal loops in vitro. With intestine from rats fed the Oxoid diet, bradykinin (100 nM in the serosal medium) caused significant increases in the rates of glucose absorption (34%, P less than 0.01) and lactate production (69%, P less than 0.01). These bradykinin-stimulated rates were the same, within experimental error, as those observed in the absence of bradykinin with intestine taken from rats fed the Bantin & Kingman diet and on which bradykinin had no effect. It is concluded that feeding rats with different commercial brands of apparently similar laboratory chow diets may result in significantly altered steady-states of glucose homeostasis in rat small intestine and in quite different sensitivities of glucose homeostasis to bradykinin. The possibility is considered that the differences in absorption might result in part from differences in the proportion of linoleic acid, which is known to enhance glucose absorption.
G L Kellett; E D Barker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  992     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  128-30     Citation Subset:  IM    
Department of Biology, University of York, U.K.
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MeSH Terms
Bradykinin / pharmacology*
Glucose / metabolism*
Intestinal Absorption / drug effects*
Jejunum / drug effects,  metabolism*
Lactates / biosynthesis
Rats, Inbred Strains
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Lactates; 50-99-7/Glucose; 58-82-2/Bradykinin

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