Document Detail

The steroid content of adrenal adenomas and measurements of aldosterone production in patients with essential hypertension and primary aldosteronism.
MedLine Citation:
PMID:  6025479     Owner:  NLM     Status:  MEDLINE    
The content of aldosterone, corticosterone, and cortisol has been assayed in normal adrenal tissue obtained at autopsy and in adrenal adenomas from both normotensive and hypertensive patients obtained at autopsy and from patients with primary aldosteronism obtained at surgery. The content of aldosterone and corticosterone in the adenomas of patients with essential hypertension was similar to that of normal adrenal tissue and much less than that of adenomas from patients with primary aldosteronism. Since these results do not appear to reflect various extraneous factors such as assay technique, degradation of steroids, and patient selection, they suggest that most adrenal adenomas found in patients with essential hypertension are not associated with increased aldosterone production. The presence of such adenomas should not, in itself, be considered evidence for primary aldosteronism. The excretion or secretion of aldosterone in 43 hypertensive patients was found to be similar to that of 39 normotensive patients. These results suggest that primary aldosteronism is rarely the cause of "essential" hypertension.
N M Kaplan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  46     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1967 May 
Date Detail:
Created Date:  1967-07-22     Completed Date:  1967-07-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  728-34     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma / metabolism*
Adrenal Gland Neoplasms / metabolism*
Aldosterone / metabolism*
Corticosterone / metabolism*
Hydrocortisone / metabolism*
Hyperaldosteronism / metabolism*
Hypertension / metabolism*
Middle Aged
Reg. No./Substance:
50-22-6/Corticosterone; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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