| The steroid content of adrenal adenomas and measurements of aldosterone production in patients with essential hypertension and primary aldosteronism. | |
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MedLine Citation:
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PMID: 6025479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The content of aldosterone, corticosterone, and cortisol has been assayed in normal adrenal tissue obtained at autopsy and in adrenal adenomas from both normotensive and hypertensive patients obtained at autopsy and from patients with primary aldosteronism obtained at surgery. The content of aldosterone and corticosterone in the adenomas of patients with essential hypertension was similar to that of normal adrenal tissue and much less than that of adenomas from patients with primary aldosteronism. Since these results do not appear to reflect various extraneous factors such as assay technique, degradation of steroids, and patient selection, they suggest that most adrenal adenomas found in patients with essential hypertension are not associated with increased aldosterone production. The presence of such adenomas should not, in itself, be considered evidence for primary aldosteronism. The excretion or secretion of aldosterone in 43 hypertensive patients was found to be similar to that of 39 normotensive patients. These results suggest that primary aldosteronism is rarely the cause of "essential" hypertension. |
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Authors:
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N M Kaplan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 46 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1967 May |
Date Detail:
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Created Date: 1967-07-22 Completed Date: 1967-07-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 728-34 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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metabolism* Adrenal Gland Neoplasms / metabolism* Adult Aged Aldosterone / metabolism* Corticosterone / metabolism* Female Humans Hydrocortisone / metabolism* Hyperaldosteronism / metabolism* Hypertension / metabolism* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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50-22-6/Corticosterone; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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