Document Detail

A steroid-cell tumor of the ovary resulting in massive androgen excess early in the gonadol steroidogenic pathway.
MedLine Citation:
PMID:  18958769     Owner:  NLM     Status:  MEDLINE    
We describe the case of a 30-year-old woman with an ovarian steroid-cell tumor secreting markedly elevated levels of testosterone (28.3 nmol/l), dehydroepiandrosterone sulfate (19.7 micromol/l), androstenedione (>34.7 nmol/l) and 17-hydroxyprogesterone (100.5 nmol/l) into plasma. We could find no report within the literature of androgens at the levels described in our patient. We review the literature and discuss the possible endocrine etiology of the excess androgens observed in this case. We also discuss the differential diagnosis, investigation and interpretation of androgens of adrenal and ovarian origin.
Jeffrey W Stephens; Andrew Fielding; Romona Verdaguer; Omar Freites
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Publication Detail:
Type:  Case Reports; Comment; Duplicate Publication; Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  24     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-29     Completed Date:  2009-01-28     Revised Date:  2012-04-25    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  502-4     Citation Subset:  IM    
Institute of Life Sciences, Swansea University, Swansea, UK.
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MeSH Terms
17-alpha-Hydroxyprogesterone / blood*
Adrenal Cortex Hormones / secretion*
Adrenal Glands / metabolism,  pathology
Androgens / blood,  secretion*
Dehydroepiandrosterone Sulfate / blood
Diagnosis, Differential
Fallopian Tubes / surgery
Ovarian Neoplasms / pathology,  secretion*,  surgery
Ovary / metabolism
Testosterone / blood
Tomography, X-Ray Computed
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Androgens; 58-22-0/Testosterone; 651-48-9/Dehydroepiandrosterone Sulfate; 68-96-2/17-alpha-Hydroxyprogesterone
Comment On:
Gynecol Endocrinol. 2008 Mar;24(3):151-3   [PMID:  18335330 ]
Erratum In:
Gynecol Endocrinol. 2012 Apr;28(4):340

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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