Document Detail


A stereological evaluation of secretin and gastric inhibitory peptide-containing mucosal cells of the perinatal small intestine of the pig.
MedLine Citation:
PMID:  15447686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stereological methods were used to quantify secretin and gastric inhibitory peptide (GIP)-immunoreactivity (GIP-IR) in paraffin sections of the duodenum, jejunum and ileum of fetal and neonatal piglets. In addition, sections were processed for GLP-1-immunohistochemistry. The volume density of the tunica mucosa increased after birth, giving rise to a decreased volume density of the tela submucosa and tunica muscularis. Generally known region-specific morphological distinctions were reflected in differing volume densities of the various layers. The highest volume density of GIP-IR epithelial cells was observed in the jejunum of the neonate. In contrast, the volume density of secretin-IR epithelial cells was highest in the duodenum of both fetal and neonatal piglets. The volume occupied by GIP-IR and secretin-IR epithelial cells increased in the jejunum after birth. Additionally, ileal secretin-IR epithelial cells were more numerous in the neonatal piglet. In conclusion, the quantitative and qualitative presence of GIP-IR and secretin-IR epithelial cells agree with earlier reports of their presence and co-localization between GIP-IR and GLP-1-IR, in the pig small intestine. Furthermore, the differences suggest that age- and region-related functional demands are temporally and probably causally related with the morphological diversification of the intestine and its endocrine cells.
Authors:
C Van Ginneken; A Weyns
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of anatomy     Volume:  205     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-27     Completed Date:  2004-12-17     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  England    
Other Details:
Languages:  eng     Pagination:  267-75     Citation Subset:  IM    
Affiliation:
Laboratory of Veterinary Anatomy & Embryology, Laboratory of Veterinary Medicine, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Belgium. chris.vanginneken@ua.ac.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / metabolism*
Gastric Inhibitory Polypeptide / analysis*
Immunohistochemistry / methods
Intestinal Mucosa / anatomy & histology,  chemistry*,  embryology
Intestine, Small* / anatomy & histology,  embryology
Secretin / analysis*
Swine / embryology,  metabolism*
Chemical
Reg. No./Substance:
1393-25-5/Secretin; 59392-49-3/Gastric Inhibitory Polypeptide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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