| A stereological evaluation of secretin and gastric inhibitory peptide-containing mucosal cells of the perinatal small intestine of the pig. | |
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MedLine Citation:
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PMID: 15447686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stereological methods were used to quantify secretin and gastric inhibitory peptide (GIP)-immunoreactivity (GIP-IR) in paraffin sections of the duodenum, jejunum and ileum of fetal and neonatal piglets. In addition, sections were processed for GLP-1-immunohistochemistry. The volume density of the tunica mucosa increased after birth, giving rise to a decreased volume density of the tela submucosa and tunica muscularis. Generally known region-specific morphological distinctions were reflected in differing volume densities of the various layers. The highest volume density of GIP-IR epithelial cells was observed in the jejunum of the neonate. In contrast, the volume density of secretin-IR epithelial cells was highest in the duodenum of both fetal and neonatal piglets. The volume occupied by GIP-IR and secretin-IR epithelial cells increased in the jejunum after birth. Additionally, ileal secretin-IR epithelial cells were more numerous in the neonatal piglet. In conclusion, the quantitative and qualitative presence of GIP-IR and secretin-IR epithelial cells agree with earlier reports of their presence and co-localization between GIP-IR and GLP-1-IR, in the pig small intestine. Furthermore, the differences suggest that age- and region-related functional demands are temporally and probably causally related with the morphological diversification of the intestine and its endocrine cells. |
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Authors:
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C Van Ginneken; A Weyns |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of anatomy Volume: 205 ISSN: 0021-8782 ISO Abbreviation: J. Anat. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-27 Completed Date: 2004-12-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0137162 Medline TA: J Anat Country: England |
Other Details:
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Languages: eng Pagination: 267-75 Citation Subset: IM |
Affiliation:
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Laboratory of Veterinary Anatomy & Embryology, Laboratory of Veterinary Medicine, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Belgium. chris.vanginneken@ua.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / metabolism* Gastric Inhibitory Polypeptide / analysis* Immunohistochemistry / methods Intestinal Mucosa / anatomy & histology, chemistry*, embryology Intestine, Small* / anatomy & histology, embryology Secretin / analysis* Swine / embryology, metabolism* |
| Chemical | |
Reg. No./Substance:
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1393-25-5/Secretin; 59392-49-3/Gastric Inhibitory Polypeptide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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