Document Detail

A step further toward glyphosate-induced epidermal cell death: Involvement of mitochondrial and oxidative mechanisms.
MedLine Citation:
PMID:  22522424     Owner:  NLM     Status:  Publisher    
A deregulation of programmed cell death mechanisms in human epidermis leads to skin pathologies. We previously showed that glyphosate, an extensively used herbicide, provoked cytotoxic effects on cultured human keratinocytes, affecting their antioxidant capacities and impairing morphological and functional cell characteristics. The aim of the present study, carried out on the human epidermal cell line HaCaT, was to examine the part of apoptosis plays in the cytotoxic effects of glyphosate and the intracellular mechanisms involved in the apoptotic events. We have conducted different incubation periods to reveal the specific events in glyphosate-induced cell death. We observed an increase in the number of early apoptotic cells at a low cytotoxicity level (15%), and then, a decrease, in favor of late apoptotic and necrotic cell rates for more severe cytotoxicity conditions. At the same time, we showed that the glyphosate-induced mitochondrial membrane potential disruption could be a cause of apoptosis in keratinocyte cultures.
Celine Heu; Celine Elie-Caille; Virginie Mougey; Sophie Launay; Laurence Nicod
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-15
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  34     ISSN:  1872-7077     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  144-153     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
University of Franche-Comte, Clinical & Innovation Proteomic Platform (CLIPP), Institut FEMTO-ST, UMR 6174 CNRS, 25030 Besancon cedex, France; University of Franche-Comte, Laboratoire de Biologie Cellulaire, EA4268, SFR FED 4234, UFR Sciences Medicales & Pharmaceutiques, 19 rue Ambroise Paré, 25030 Besancon cedex, France.
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