Document Detail


A step change towards risk assessment in the 21st century .
MedLine Citation:
PMID:  23276999     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Chemical Regulation and the means by which data is generated for the purposes of risk assessment is undergoing a tremendous shift. There is a strong impetus in Europe, in particular, to move towards non-animal approaches to address data gaps for specific endpoints either in lieu of testing or as part of weight of evidence approaches within integrated testing strategies (ITS). An Exposure assessment considering workers and/or consumers is a critical component of a robust risk assessment. The EU chemicals legislation REACH, for example, provides considerable flexibility in the application of non-testing approaches such as (Q)SARs, chemical categories and read-across for data gap filling. There have been a number of efforts aimed at developing technical guidance, tools, and techniques for non-testing and tiered exposure approaches. Despite these efforts, there remains limited practical insight about how these approaches can be applied in the assessment of substances. Here, we first provide a background of the available approaches and how they can and should be practically utilised to address REACH requirements.
Authors:
Grace Yvonne Patlewicz; Deborah Rosemary Lander
Related Documents :
20693039 - New epidermal model for dermal irritancy testing.
128349 - Skin irritancy and sensitivity to laundry detergents containing proteolytic enzymes. pa...
14623479 - Proposal for a risk assessment methodology for skin sensitization based on sensitizatio...
11769249 - Allergenic (sensitization, skin and eye irritation) effects of freshwater cyanobacteria...
11171519 - The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airbor...
23763529 - Economic evaluations of point of care testing strategies for active tuberculosis.
22721509 - Progressive brain atrophy in patients with chronic neuropsychiatric symptoms after mild...
22515029 - Performance of complement fixation test and confirmatory immunoblot as two-cascade test...
23075249 - Repeating tests: different roles in research studies and clinical medicine.
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-34     Citation Subset:  IM    
Affiliation:
DuPont Haskell Global Centers for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE 19711.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Plants genetic manipulation: an approach from intellectual property .
Next Document:  Ethical and legal issues in the clinical practice of primary health care .