Document Detail

A step change towards risk assessment in the 21st century .
MedLine Citation:
PMID:  23276999     Owner:  NLM     Status:  In-Data-Review    
Chemical Regulation and the means by which data is generated for the purposes of risk assessment is undergoing a tremendous shift. There is a strong impetus in Europe, in particular, to move towards non-animal approaches to address data gaps for specific endpoints either in lieu of testing or as part of weight of evidence approaches within integrated testing strategies (ITS). An Exposure assessment considering workers and/or consumers is a critical component of a robust risk assessment. The EU chemicals legislation REACH, for example, provides considerable flexibility in the application of non-testing approaches such as (Q)SARs, chemical categories and read-across for data gap filling. There have been a number of efforts aimed at developing technical guidance, tools, and techniques for non-testing and tiered exposure approaches. Despite these efforts, there remains limited practical insight about how these approaches can be applied in the assessment of substances. Here, we first provide a background of the available approaches and how they can and should be practically utilised to address REACH requirements.
Grace Yvonne Patlewicz; Deborah Rosemary Lander
Related Documents :
20471469 - Adaptation of the validated skinethic reconstructed human epidermis (rhe) skin corrosio...
11171519 - The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airbor...
4070929 - Skin irritation testing in rabbits complicated by dermal mucormycosis.
16626379 - The behind-the-knee test: an efficient model for evaluating mechanical and chemical irr...
1428469 - Human test models for bioequivalence of topical corticosteroids: a review.
467029 - The duhring chamber. an improved technique for epicutaneous testing of irritant and all...
378449 - Differences between welsh and canadian children on parts of the test of motor impairment.
15756219 - Syncope in children: diagnostic tests have a high cost and low yield.
6671359 - Staphylococcus aureus latex agglutination (lat-sa) test for the diagnosis of s. aureus ...
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-34     Citation Subset:  IM    
DuPont Haskell Global Centers for Health and Environmental Sciences, 1090 Elkton Road, Newark, DE 19711.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Plants genetic manipulation: an approach from intellectual property .
Next Document:  Ethical and legal issues in the clinical practice of primary health care .