Document Detail


A steady-state electrochemical model of vascular smooth muscle cells.
MedLine Citation:
PMID:  16766616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model of the steady-state electrochemical response of vascular smooth muscle cells to external stimuli is presented, which accounts for K, Na, and Ca fluxes. The results of the model are broadly in accordance with experimental data 1), at various transmural pressures; 2), with channel and pump blockade; and 3), under manipulation of external ionic concentrations. The model exhibits dual stable states which sometimes coexist, and abrupt transitions between these states may account for nongraded responses in arteries as external potassium or pressure is varied. The simulations suggest that changes in the intracellular sodium concentration ([Na]i) often accompany smooth muscle responses. For example, [Na]i values vary threefold over the range of pressures from 10 to 100 mmHg.
Authors:
Masood A Machingal; S V Ramanan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-09
Journal Detail:
Title:  Biophysical journal     Volume:  91     ISSN:  0006-3495     ISO Abbreviation:  Biophys. J.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-16     Completed Date:  2006-10-05     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1648-62     Citation Subset:  IM    
Affiliation:
AU-KBC Research Centre, MIT Campus of Anna University, Chromepet, Chennai, India 600044, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Computer Simulation
Electrochemistry / methods
Hemostasis / physiology*
Humans
Ion Channel Gating / physiology
Ion Channels / physiology*
Membrane Potentials / physiology
Models, Cardiovascular*
Muscle Contraction / physiology*
Muscle, Smooth, Vascular / physiology*
Vasoconstriction / physiology*
Vasodilation / physiology*
Chemical
Reg. No./Substance:
0/Ion Channels
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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