Document Detail

Oxidant/antioxidant status in patients with recurrent aphthous stomatitis.
MedLine Citation:
PMID:  14616834     Owner:  NLM     Status:  MEDLINE    
Recurrent aphthous stomatitis (RAS) is recognized as one of the most common oral mucosal diseases worldwide. The aim of this study was to determine the oxidant/antioxidant status in erythrocyte and plasma samples from patients with RAS in comparison with healthy controls. Twenty-two patients with RAS and 23 healthy controls were recruited. Superoxide dismutase, glutathione peroxidase (GSHPx) and catalase (CAT) activities, and malondialdehyde (MDA) and antioxidant potential (AOP) levels were measured in plasma and erythrocytes from patient with RAS and controls. We found decreased CAT and GSHPx activities and AOP levels in the erythrocytes, and decreased AOP and increased MDA plasma levels in patients with RAS in comparison with control subjects. In summary, this study demonstrated that enzymatic and nonenzymatic antioxidant defence systems are impaired in patients with RAS.
M Y B Cimen; T I Kaya; G Eskandari; U Tursen; G Ikizoglu; U Atik
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  28     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2003-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  647-50     Citation Subset:  IM    
Department of Biochemistry, School of Medicine, Mersin University, Mersin, Turkey.
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MeSH Terms
Antioxidants / metabolism*
Ascorbic Acid / therapeutic use
Catalase / blood
Erythrocytes / enzymology,  metabolism
Glutathione Peroxidase / blood
Malondialdehyde / blood
Middle Aged
Oxidants / blood*
Prospective Studies
Selenium / therapeutic use
Stomatitis, Aphthous / drug therapy,  enzymology,  metabolism*
Superoxide Dismutase / blood
Reg. No./Substance:
0/Antioxidants; 0/Oxidants; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde; 7782-49-2/Selenium; EC; EC Peroxidase; EC Dismutase

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