| The status of dopamine nerve terminals in Parkinson's disease and essential tremor: a PET study with the tracer [11-C]FE-CIT. | |
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MedLine Citation:
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PMID: 11487195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuroimaging studies of the striatal dopamine transporter (DAT) are useful in the assessment of the dopaminergic system in Parkinson's disease (PD). We used positron emisson tomography (PET) and the tracer [11C]FE-CIT to measure DAT binding in the caudate nucleus and putamen of 31 patients with PD, 5 with essential tremor and 8 healthy control subjects. Of the patients with PD, 17 were drug naive, while the others were either on levodopa or dopamine agonist monotherapy. DAT binding was significantly reduced in the caudate nucleus and to a greater extent in the putamen of PD patients compared to both healthy controls and essential tremor individuals. No overlap was observed between putamen values in PD and normals. No differences were found between controls and essential tremor subjects. These data confirm that measurements of DAT binding can provide an accurate and highly sensitive measure of degeneration in the dopamine system in PD. |
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Authors:
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A Antonini; R M Moresco; C Gobbo; R De Notaris; A Panzacchi; P Barone; S Calzetti; A Negrotti; G Pezzoli; F Fazio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 22 ISSN: 1590-1874 ISO Abbreviation: Neurol. Sci. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-08-06 Completed Date: 2001-12-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 47-8 Citation Subset: IM |
Affiliation:
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Department of Neurosciences, Istituti Clinici di Perfezionamento, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Radioisotopes
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diagnostic use* Dopamine Plasma Membrane Transport Proteins Essential Tremor / physiopathology, radionuclide imaging* Humans Membrane Glycoproteins* Membrane Transport Proteins / metabolism* Middle Aged Neostriatum / physiopathology, radionuclide imaging* Nerve Tissue Proteins* Nortropanes / diagnostic use* Parkinson Disease / physiopathology, radionuclide imaging* Presynaptic Terminals / radionuclide imaging* Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Dopamine Plasma Membrane Transport Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/N-(2-fluoroethyl)-2-carbomethoxy-3-(4-iodophenyl)nortropane; 0/Nerve Tissue Proteins; 0/Nortropanes; 0/SLC6A3 protein, human |
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