Document Detail

The status of dopamine nerve terminals in Parkinson's disease and essential tremor: a PET study with the tracer [11-C]FE-CIT.
MedLine Citation:
PMID:  11487195     Owner:  NLM     Status:  MEDLINE    
Neuroimaging studies of the striatal dopamine transporter (DAT) are useful in the assessment of the dopaminergic system in Parkinson's disease (PD). We used positron emisson tomography (PET) and the tracer [11C]FE-CIT to measure DAT binding in the caudate nucleus and putamen of 31 patients with PD, 5 with essential tremor and 8 healthy control subjects. Of the patients with PD, 17 were drug naive, while the others were either on levodopa or dopamine agonist monotherapy. DAT binding was significantly reduced in the caudate nucleus and to a greater extent in the putamen of PD patients compared to both healthy controls and essential tremor individuals. No overlap was observed between putamen values in PD and normals. No differences were found between controls and essential tremor subjects. These data confirm that measurements of DAT binding can provide an accurate and highly sensitive measure of degeneration in the dopamine system in PD.
A Antonini; R M Moresco; C Gobbo; R De Notaris; A Panzacchi; P Barone; S Calzetti; A Negrotti; G Pezzoli; F Fazio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  22     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-08-06     Completed Date:  2001-12-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  47-8     Citation Subset:  IM    
Department of Neurosciences, Istituti Clinici di Perfezionamento, Milan, Italy.
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MeSH Terms
Carbon Radioisotopes / diagnostic use*
Dopamine Plasma Membrane Transport Proteins
Essential Tremor / physiopathology,  radionuclide imaging*
Membrane Glycoproteins*
Membrane Transport Proteins / metabolism*
Middle Aged
Neostriatum / physiopathology,  radionuclide imaging*
Nerve Tissue Proteins*
Nortropanes / diagnostic use*
Parkinson Disease / physiopathology,  radionuclide imaging*
Presynaptic Terminals / radionuclide imaging*
Tomography, Emission-Computed
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Dopamine Plasma Membrane Transport Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/N-(2-fluoroethyl)-2-carbomethoxy-3-(4-iodophenyl)nortropane; 0/Nerve Tissue Proteins; 0/Nortropanes; 0/SLC6A3 protein, human

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