Document Detail

The status of dental and jaw bones in children and adolescents after kidney and liver transplantation.
MedLine Citation:
PMID:  23274327     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Systemic complications in patients after renal or liver transplantation may be localized in the oral cavity. Calcium-phosphate disturbances may affect the structure and metabolism of mandible bones, promote calcification of dental pulp, and in children may cause developmental defects of teeth. The aim of this study was to evaluate the incidence of dental and bone abnormalities in children and adolescents after kidney and liver transplantation with respect to the type of the transplanted organ and maintenance immunosuppression.
MATERIAL/METHODS: Overall, 23 kidney and 25 liver recipients (mean age: 13.95±4.2 yrs) were evaluated. Twenty patients received ciclosporin A (CsA) and 28 tacrolimus (TAC). Twenty-one kidney and 14 liver recipients were treated with steroids. Mean time after transplantation was 3.62±2.98 years.
RESULTS: The severity of caries and percentage of odontogenic abnormalities (76.0% vs. 60.86%) was higher in liver transplant recipients. Positive correlations were found between discoloration of the deciduous teeth and liver transplantation, between enamel hypoplasia and kidney transplantation, and between treatment with CsA and its dose and blood concentration (p<0.05). Pulp stones were present in 13.04% of kidney vs. 8.0% in liver recipients, more often in those treated with CsA than with TAC. Jaw bone abnormalities were present in 30.43% kidney recipients vs. 12% liver recipients.
CONCLUSIONS: Both kidney and liver recipients present dental and bone abnormalities. The incidence of specific types of oral lesions is different in renal and liver graft recipients; however, it is also correlated with specific immunosuppression.
Dorota Olczak-Kowalczyk; Dariusz Gozdowski; Joanna Pawłowska; Ryszard Grenda
Related Documents :
3594937 - The glomerular tip lesion: a steroid responsive nephrotic syndrome.
14551357 - Tubular staining of modified c-reactive protein in diabetic chronic kidney disease.
11149127 - Progeria kidney has abnormal mesangial collagen distribution.
18436087 - Renal biopsy findings in children and adolescents with fabry disease and minimal albumi...
25183177 - Sinonasal disorders in hematopoietic stem cell transplantation.
3528537 - Cardiac transplantation in an 8-month-old female infant with subendocardial fibroelasto...
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Annals of transplantation : quarterly of the Polish Transplantation Society     Volume:  17     ISSN:  2329-0358     ISO Abbreviation:  Ann. Transplant.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-05-28     Revised Date:  2013-06-17    
Medline Journal Info:
Nlm Unique ID:  9802544     Medline TA:  Ann Transplant     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  72-81     Citation Subset:  IM    
Department of Paediatric Dentistry, Medical University of Warsaw, Warsaw, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Cyclosporine / adverse effects,  therapeutic use
Dental Caries / etiology
Dental Enamel Hypoplasia / etiology
Dental Pulp Calcification / etiology
Glucocorticoids / adverse effects,  therapeutic use
Graft Rejection / prevention & control
Immunosuppressive Agents / adverse effects*,  therapeutic use
Jaw Diseases / epidemiology,  etiology*
Kidney Transplantation* / immunology
Liver Transplantation* / immunology
Postoperative Complications* / epidemiology
Retrospective Studies
Tacrolimus / adverse effects,  therapeutic use
Tooth Discoloration / etiology
Tooth Diseases / epidemiology,  etiology*
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Predictive factors associated with re-exploration for hemostasis in living donor liver transplantati...
Next Document:  Cost analysis of kidney transplantation in highly sensitized recipients compared to intermittent mai...