Document Detail


On the statistical modelling of coronary arteriographic data: dynamics of coronary atherosclerosis related to systemic and focal parameters. REGRESS Study Group. Regression Growth Evaluation Statin Study.
MedLine Citation:
PMID:  9483717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Existing methods to analyse data from repeated arteriographic progression/regression studies are restrictive and do not fully explore the dynamics of coronary artherosclerosis. We present a new approach making a distinction between new occlusions, new lesions, and growth of existing lesions. Random effect models, based on the logistic, the Poisson, and the normal distribution are proposed with correlation depending on distance. The data from the Regression Growth Evaluation Statin Study (REGRESS) are used to validate the model. Lipid lowering treatment of pravastatin resulted in less growth of existing lesions and fewer new lesions than when placebo was given. Fewer new lesions were found in segments influenced by percutaneous transluminal coronary angioplasty (PTCA) than in segments not influenced by PTCA. Similarly, the growth of lesions influenced by PTCA was smaller than lesions not influenced by PTCA. More new occlusions were found in segments influenced by coronary arterial bypass grafting (CABG) than in segments not influenced by CABG, but 98 per cent of the new occlusions were located proximal to the bypass anastomosis. Similarly, existing lesions proximal to the bypass anastomosis showed larger growth (p < 0.001). We conclude that our new approach for analysing the arteriographic data from repeated coronary arteriographic studies appeared a fruitful way to analyse the dynamics of coronary atherosclerosis.
Authors:
A H Zwinderman; J W Jukema; A J van Boven; J H Reiber
Related Documents :
10689257 - A comparison of electrocardiographic changes during reperfusion of acute myocardial inf...
2510487 - The cost:benefit ratio of acute intervention for myocardial infarction: results of a pr...
1460497 - Early thallium imaging after percutaneous transluminal coronary angioplasty: tomographi...
2956837 - Influence of the methodology of percutaneous transluminal coronary angioplasty on reste...
10672407 - Incessant ectopic atrial tachycardia and tachycardia-related cardiomyopathy: therapeuti...
11127007 - Doppler echocardiographic evaluation of right ventricular function in patients with rig...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Statistics in medicine     Volume:  16     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-23     Completed Date:  1998-04-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2829-41     Citation Subset:  IM    
Affiliation:
Department of Medical Statistics, Leiden University Hospital, The Netherlands. a.h.zwinderman@medstat.medfac.leidenuniv.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angioplasty, Transluminal, Percutaneous Coronary
Anticholesteremic Agents / therapeutic use
Coronary Angiography*
Coronary Artery Bypass
Coronary Artery Disease / pathology*,  radiography,  therapy
Humans
Likelihood Functions
Models, Biological*
Pravastatin / therapeutic use
Regression Analysis
Statistics as Topic / methods*
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 81093-37-0/Pravastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Resampling and cross-validation techniques: a tool to reduce bias caused by model building?
Next Document:  Clustered binary logistic regression in teratology data using a finite mixture distribution.