| On the statistical modelling of coronary arteriographic data: dynamics of coronary atherosclerosis related to systemic and focal parameters. REGRESS Study Group. Regression Growth Evaluation Statin Study. | |
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MedLine Citation:
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PMID: 9483717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Existing methods to analyse data from repeated arteriographic progression/regression studies are restrictive and do not fully explore the dynamics of coronary artherosclerosis. We present a new approach making a distinction between new occlusions, new lesions, and growth of existing lesions. Random effect models, based on the logistic, the Poisson, and the normal distribution are proposed with correlation depending on distance. The data from the Regression Growth Evaluation Statin Study (REGRESS) are used to validate the model. Lipid lowering treatment of pravastatin resulted in less growth of existing lesions and fewer new lesions than when placebo was given. Fewer new lesions were found in segments influenced by percutaneous transluminal coronary angioplasty (PTCA) than in segments not influenced by PTCA. Similarly, the growth of lesions influenced by PTCA was smaller than lesions not influenced by PTCA. More new occlusions were found in segments influenced by coronary arterial bypass grafting (CABG) than in segments not influenced by CABG, but 98 per cent of the new occlusions were located proximal to the bypass anastomosis. Similarly, existing lesions proximal to the bypass anastomosis showed larger growth (p < 0.001). We conclude that our new approach for analysing the arteriographic data from repeated coronary arteriographic studies appeared a fruitful way to analyse the dynamics of coronary atherosclerosis. |
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Authors:
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A H Zwinderman; J W Jukema; A J van Boven; J H Reiber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Statistics in medicine Volume: 16 ISSN: 0277-6715 ISO Abbreviation: Stat Med Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-04-23 Completed Date: 1998-04-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8215016 Medline TA: Stat Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2829-41 Citation Subset: IM |
Affiliation:
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Department of Medical Statistics, Leiden University Hospital, The Netherlands. a.h.zwinderman@medstat.medfac.leidenuniv.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Anticholesteremic Agents / therapeutic use Coronary Angiography* Coronary Artery Bypass Coronary Artery Disease / pathology*, radiography, therapy Humans Likelihood Functions Models, Biological* Pravastatin / therapeutic use Regression Analysis Statistics as Topic / methods* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 81093-37-0/Pravastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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