Document Detail


A statistical mechanical treatment of fatty acyl chain order in phospholipid bilayers and correlation with experimental data. B. Dipalmitoyl-3-sn-phosphatidylcholine.
MedLine Citation:
PMID:  6895036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to help bridge the conceptual gap between experimental data on chains of phospholipid molecules and their microscopic organization, a theoretical model has proposed in a preceding paper. The intentions associated with the new theory were to describe a model able to reproduce accurately the experimental data. This capability is essential to monitor some of the mechanisms behind the physical data. The results presented here show first that, provided a suitable fitting of the phenomenological parameters entailed in the model, the theory indeed gives good agreement with experimental data (2H-NMR, neutron scattering, calorimetry) obtained for a dipalmitoyl-3-sn-phosphatidylcholine bilayer. This property of the model is then specifically used to describe the nature of the perturbing effects of local anaesthetics and cholesterol on the organization of the acyl chains and to correlate these effects with the experimental data. Finally the theoretical model is used to supplement experimental data by describing the acyl chain organization in terms of the most probable spectrum of chain conformations. Predictions are made about the one-, two- and three-dimensional mean spatial characteristics of the acyl chains.
Authors:
J P Meraldi; J Schlitter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  645     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-210     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acylation
Fatty Acids
Lipid Bilayers*
Magnetic Resonance Spectroscopy
Models, Theoretical
Molecular Conformation
Neutrons
Phospholipids*
Probability
Pulmonary Surfactants / analysis
Scattering, Radiation
Thermodynamics
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Lipid Bilayers; 0/Phospholipids; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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