Document Detail


The statistical analysis of adherence data obtained from markers.
MedLine Citation:
PMID:  6518784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adherence markers provide new kinds of clinical trial data. Adherence data on individual participants obtained from markers can be used for designing the trial sample size and stratification, evaluating the adequacy of randomization, directing the management of adherence, and analyzing and interpreting the trial's final results. Examples of these are presented. Analyses of adherence data can employ conventional procedures. Box plot techniques are proposed for flagging extreme values of the distribution of adherence either at a single time point or in a time continuum. The effect of difference in distribution of the markers in two or more groups in a clinical trial is discussed. Survival analysis is illustrated as one technique in univariate and multivariate analysis of markers with covariate effects. Design considerations with markers in a clinical trial are discussed, with particular emphasis on some of the assumptions and biases that must be considered for the analysis.
Authors:
A Silvers; M L Russell; W Insull
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Controlled clinical trials     Volume:  5     ISSN:  0197-2456     ISO Abbreviation:  Control Clin Trials     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-03-13     Completed Date:  1985-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006242     Medline TA:  Control Clin Trials     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  544-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic*
Humans
Patient Compliance*
Statistics as Topic
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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