Document Detail


The stationary-phase sigma factor sigma(S) is responsible for the resistance of Escherichia coli stationary-phase cells to mazEF-mediated cell death.
MedLine Citation:
PMID:  19251848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Escherichia coli mazEF is a toxin-antitoxin gene module that mediates cell death during exponential-phase cellular growth through either reactive oxygen species (ROS)-dependent or ROS-independent pathways. Here, we found that the stationary-phase sigma factor sigma(S) was responsible for the resistance to mazEF-mediated cell death during stationary growth phase. Deletion of rpoS, the gene encoding sigma(S) from the bacterial chromosome, permitted mazEF-mediated cell death during stationary growth phase.
Authors:
Ilana Kolodkin-Gal; Hanna Engelberg-Kulka
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-02-27
Journal Detail:
Title:  Journal of bacteriology     Volume:  191     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-16     Completed Date:  2009-05-15     Revised Date:  2010-09-22    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3177-82     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, the Hebrew University-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / genetics,  physiology*
Colony Count, Microbial
DNA-Binding Proteins / biosynthesis*
Endoribonucleases / biosynthesis*
Escherichia coli / physiology*
Escherichia coli Proteins / biosynthesis*
Gene Deletion
Gene Expression Regulation, Bacterial*
Microbial Viability*
Sigma Factor / genetics,  physiology*
Grant Support
ID/Acronym/Agency:
GM069509/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/DNA-Binding Proteins; 0/Escherichia coli Proteins; 0/MazE protein, E coli; 0/MazF protein, E coli; 0/Sigma Factor; 0/sigma factor KatF protein, Bacteria; EC 3.1.-/Endoribonucleases
Comments/Corrections

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