| The stathmokinetic and morphological response of the hamster respiratory epithelium to intralaryngeal instillations of saline and ferric oxide in saline. | |
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MedLine Citation:
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PMID: 3692025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ferric oxide (Fe2O3) and saline, substances which enhance lung tumor development when intratracheally instilled with certain carcinogens, were studied for their effects on respiratory epithelial cell proliferation in Syrian golden hamsters. Groups of hamsters were given intralaryngeal instillations of 0.2 ml saline or 3 mg Fe2O3 in 0.2 ml saline (Fe2O3-saline) once a week for 5, 10, or 15 weeks; an additional group of hamsters received a single Fe2O3-saline instillation. Epithelial mitotic rates (MR, 6 hr colchicine blockade) for the midtrachea, left intrapulmonary bronchus, and left lung bronchioles were determined 32 hr after the last instillation for each group. No change in the MR was seen at any airway level for any of the saline-treated groups. There was also no change in the MR of the trachea or bronchus for any of the groups treated with Fe2O3-saline. The MR of the bronchioles was increased after 5 instillations of Fe2O3-saline. Fe2O3-saline instillations also caused bronchioloalveolar hyperplasia (BAH) to develop by 5 instillations, but after 10 and 15 treatments BAH was less prominent. These data indicate that intralaryngeal Fe2O3-saline instillations result in focal cell injury followed by proliferation in the distal airways, but multiple long-term treatments produce an adaptive response of the respiratory epithelium. |
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Authors:
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H E Marshall; K P Keenan; E M McDowell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fundamental and applied toxicology : official journal of the Society of Toxicology Volume: 9 ISSN: 0272-0590 ISO Abbreviation: Fundam Appl Toxicol Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1988-02-03 Completed Date: 1988-02-03 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8200838 Medline TA: Fundam Appl Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 705-14 Citation Subset: IM |
Affiliation:
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University of Maryland, Department of Pathology, School of Medicine, Baltimore 21201. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cricetinae Epithelium / drug effects, metabolism, pathology Ferric Compounds / toxicity* Larynx / drug effects*, pathology Male Mesocricetus Mitosis / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 1309-37-1/ferric oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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