| "On" state freezing of gait in Parkinson disease: A paradoxical levodopa-induced complication. | |
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MedLine Citation:
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PMID: 22262741 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:To describe the phenotype of levodopa-induced "on" freezing of gait (FOG) in Parkinson disease (PD). METHODS:We present a diagnostic approach to separate "on" FOG (deterioration during the "on state") from other FOG forms. Four patients with PD with suspected "on" FOG were examined in the "off state" (>12 hours after last medication intake), "on state" (peak effect of usual medication), and "supra-on" state (after intake of at least twice the usual dose). RESULTS:Patients showed clear "on" FOG, which worsened in a dose-dependent fashion from the "on" to the "supra-on" state. Two patients also demonstrated FOG during the "off state," of lesser magnitude than during "on." In addition, levodopa produced motor blocks in hand and feet movements, while other parkinsonian features improved. None of the patients had cognitive impairment or a predating "off" FOG. CONCLUSIONS:True "on" FOG exists as a rare phenotype in PD, unassociated with cognitive impairment or a predating "off" FOG. Distinguishing the different FOG subtypes requires a comprehensive motor assessment in at least 3 medication states. |
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Authors:
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A J Espay; A Fasano; B F L van Nuenen; M M Payne; A H Snijders; B R Bloem |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: Neurology Volume: - ISSN: 1526-632X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the UC Neuroscience Institute (A.J.E., M.M.P.), Department of Neurology, Gardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, Cincinnati, OH; I.R.C.C.S. Neuromed (A.F.), Pozzilli (IS), Italy; and Department of Neurology (B.F.L.v.N., A.H.S., B.R.B.), Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Center, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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