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The stars within the melanocytic garden: Unusual variants of Spitz nevi.
MedLine Citation:
PMID:  25123161     Owner:  NLM     Status:  Publisher    
BACKGROUND: Spitz nevi may present a wide spectrum of morphologies. Histopathologically, many variants, including desmoplastic, angiomatoid, verrucous/polypoid, plexiform, pagetoid, halo, myxoid, granulomatous, and tubular Spitz nevi, have been described. Clinical and dermoscopic features of these unusual variants of Spitz nevi have been rarely reported.
OBJECTIVES: The aim of this study is to describe clinical, dermoscopic and histopathological features of uncommon morphological variants of Spitz nevi, in order to arise awareness among clinicians about their peculiar patterns of presentation.
METHODS: We retrospectively searched our image database from 2004 to 2014 for images of excised tumors using Spitz/Reed nevus as keyword.
RESULTS: A total of 307 skin excised lesions with a histopathological diagnosis of Spitz/Reed nevus were found. Among those we identified 13 uncommon variants of Spitz nevi including 6 cases of desmoplastic Spitz nevus, 5 cases of angiomatoid Spitz nevus and 2 cases of verrucous Spitz nevus. All lesions were not fulfilling the already described dermoscopic criteria of Spitz nevi, with the exception of angiomatoid Spitz nevi, exhibiting a pinkish background and dotted vessels in dermoscopy. Desmoplatic Spitz nevi may be difficult to differentiate form dermatofibroma clinically, and from melanoma under dermoscopic examination. Verrucous Spitz nevi, despite their relatively unusual clinical features, show reassuring morphological clues histologically, that allow the differential diagnosis from an atypical spitzoid tumor.
CONCLUSIONS: Under dermoscopy, in all cases an atypical melanocytic lesion could not be excluded, thus warranting excision and histopathologic examination. This article is protected by copyright. All rights reserved.
E Moscarella; S Al Jalbout; S Piana; G Argenziano; A Lallas; C Longo; R Hofmann-Wellenhof; I Zalaudek
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-13
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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