Document Detail


A starring role for stellate cells in the pancreatic cancer microenvironment.
MedLine Citation:
PMID:  23622130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pancreatic cancer research began to change with the identification of pancreatic stellate cells, which produce the pancreatic tumor stroma. There is compelling in vitro and in vivo evidence for the influence of pancreatic stellate cells on pancreatic cancer development; several recent preclinical studies have reported encouraging results with approaches designed to target pancreatic stellate cells and the stroma. We review the background and recent advances in these areas, along with important areas of future research that could improve therapy.
Authors:
Minoti V Apte; Jeremy S Wilson; Aurelia Lugea; Stephen J Pandol
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  144     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-06-20     Revised Date:  2013-08-02    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1210-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
Affiliation:
Pancreatic Research Groups, University of New South Wales Sydney, New South Wales, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Pancreatic Ductal / metabolism,  pathology*,  therapy
Cell Communication
Cells, Cultured
Coculture Techniques
Disease Models, Animal
Humans
Pancreas / metabolism,  pathology*
Pancreatic Neoplasms / metabolism,  pathology*,  therapy
Pancreatic Stellate Cells / metabolism,  pathology*
Signal Transduction
Stromal Cells / metabolism,  pathology
Tumor Microenvironment*
Grant Support
ID/Acronym/Agency:
R01 AA019954/AA/NIAAA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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