Document Detail

The staphylococcal scalded skin syndrome. An experimental histochemical and electron microscopic study.
MedLine Citation:
PMID:  871383     Owner:  NLM     Status:  MEDLINE    
Histochemical and electron microscopic studies were carried out on the newborn mouse model of the staphylococcal scalded skin syndrome to investigate the mechanism of action of the staphylococcal epidermolytic toxin that causes it. Histochemical studies showed that an intra-epidermal split develops below the subcorneal zone which is rich in catabolic enzymes (the so-called esterase-acid phosphatase-rich band). However, histochemical alterations in the enzyme pattern could not be demonstrated. The earliest change revealed by electron microscopy was a widening of the intercellular space, with the formation of microvilli at the level between the stratum spinosum and stratum granulosum where the split later occurs. A clearing of the peripheral cytoplasm along the cell membranes was also revealed. In pre-split areas, adhesion between cell membranes of adjacent cells seems to be lost; desmosomes continue to hold the cells together but the split develops when these are broken by mechanical pressure. Later, damaged cell membranes may be seen. Extracellular keratinosomes remain unchanged. Although these findings do not agree with the already divergent results of other studies, they help support the findings of all groups that cases of the Lyell syndrome produced by staphylococci do not occur through necrolysis; it is therefore inappropriate to continue applying the term 'toxic epidermal necrolysis' to such cases.
R L Dimond; H H Wolff; O Braun-Falco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  96     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  483-92     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Bacterial Toxins*
Biological Assay
Epidermal Necrolysis, Toxic / enzymology,  etiology,  microbiology,  pathology*
Microscopy, Electron
Skin / ultrastructure
Staphylococcal Infections / complications*
Staphylococcus / isolation & purification*
Toxins, Biological / analysis
Reg. No./Substance:
0/Bacterial Toxins; 0/Toxins, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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