| A standardized method of generating time-to-peak perfusion maps in dynamic-susceptibility contrast-enhanced MR imaging. | |
| | |
MedLine Citation:
|
PMID: 10954268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Perfusion MR imaging, performed as dynamic-susceptibility contrast-enhanced MR imaging, is sensitive to hemodynamic risks for patients with cerebrovascular disease. We sought to define a quantitative parameter for perfusion MR imaging, which shows brain areas at hemodynamic risk and enables direct comparison of different perfusion MR imaging examinations. METHODS: A new standardization procedure for the time-to-peak (TTP) parameter, standardized time to peak (stdTTP), was introduced. The stdTTP automatically calculates a time offset correlated to the earliest enhancing voxels in a section and rescales all TTP values accordingly. Because of a close relation between this offset and stdTTP of early enhancing voxels in central vascular territories (CVTs), stdTTP provides an estimate of the bolus run time between CVTs and related border zones (BZs). The stdTTP in CVTs and BZs was measured in 11 patients without hemodynamic impairment by using high temporal resolution dynamic-susceptibility contrast-enhanced perfusion MR imaging. RESULTS: An excellent comparability of different dynamic susceptibility contrast-enhanced MR imaging studies was found. The stdTTP in CVTs was 0.4 +/- 0.5 s (minimum, 0 s; maximum, 1.3 s) for the anterior, 0.5 +/- 0.3 s (minimum, 0 s; maximum, 1.0 s) for the middle, and 1.4 +/- 0.5 s (minimum, 0.4 s; maximum, 2.4 s) for the posterior cerebral artery. In the anterior BZ, stdTTP was 2.3 +/- 0.4 s (minimum, 1.6 s; maximum, 3.2 s), and in the posterior BZ, stdTTP was 2.8 +/- 0.4 s (minimum, 2.0 s; maximum, 3.4 s). CONCLUSION: The results suggest a limit for stdTTP of approximately 3.5 s in the anterior and posterior BZs. The stdTTP could serve as a quantitative measure for the hemodynamic risk assessment of patients with cerebrovascular disease. Because stdTTP can be directly derived from the measured curves, the hemodynamic situation of a patient can be judged with a minimum of computational effort. |
| | |
Authors:
|
C Nasel; A Azizi; A Veintimilla; R Mallek; E Schindler |
Related Documents
:
|
18504748 - Dynamic mri, dynamic multidetector-row computed tomography (mdct), and coregistered 2-[... 16373758 - Diagnostic architectural and dynamic features at breast mr imaging: multicenter study. 22143348 - Study of inferior dental canal and its contents using high-resolution magnetic resonanc... 12874518 - Comparing dynamic parameters of tumor vascularization in nude mice revealed by magnetic... 16917448 - Rate and prediction of traumatic injuries detected by abdominal computed tomography sca... 8031218 - Comparison of mr angiography with x-ray angiography in patients with ischemic cerebrova... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: 21 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2000 Aug |
Date Detail:
|
Created Date: 2001-01-11 Completed Date: 2001-01-11 Revised Date: 2008-02-14 |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1195-8 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood-Brain Barrier / physiology Brain / blood supply* Contrast Media* Epilepsy / diagnosis*, physiopathology Female Hemodynamics / physiology* Humans Image Enhancement* Image Processing, Computer-Assisted* Magnetic Resonance Imaging / methods* Male Reference Values Regional Blood Flow / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diffusion measurements in intracranial hematomas: implications for MR imaging of acute stroke.
Next Document: Posterior reversible encephalopathy syndrome: utility of fluid-attenuated inversion recovery MR imag...