Document Detail

A standardized core set for systemic sclerosis clinical trials. First step in development of combined response index.
MedLine Citation:
PMID:  18784137     Owner:  NLM     Status:  MEDLINE    
SSc can be associated with a high morbidity and mortality. Due to the complexity and heterogeneity of the disease, a composite response measure that will capture differing organ involvements and patient-reported outcomes is desirable. Recently, with participation of the Scleroderma Clinical Trial Consortium, a standardized core set of items were proposed for SSc clinical trials using a structured Delphi exercise. The Delphi exercise identified 11 domains relevant to SSc clinical trials. Currently, efforts are under way to develop a combined response index for clinical trials in diffuse cutaneous SSc.
D Khanna
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  47 Suppl 5     ISSN:  1462-0332     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-11     Completed Date:  2009-05-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  v31-2     Citation Subset:  AIM; IM    
Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
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MeSH Terms
Clinical Trials as Topic*
Health Status Indicators
Reference Standards*
Research Design
Scleroderma, Systemic / drug therapy*
Treatment Outcome
Grant Support
K23 AR053858-01A1/AR/NIAMS NIH HHS; U01 AR055057-01/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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