Document Detail

A standard blood bank donation alters the thermal and cardiovascular responses during subsequent exercise.
MedLine Citation:
PMID:  22452709     Owner:  NLM     Status:  Publisher    
BACKGROUND: The fear for adverse effects of blood donation on subsequent exercise may prevent physically active people from donating. We studied the impact of a standard blood bank donation (i.e., 450-mL blood withdrawal) on the thermoregulatory and cardiovascular responses to prolonged exercise in the heat. STUDY DESIGN AND METHODS: Eight moderately trained, heat-acclimated males cycled for 1 hour at 60% in a hot environment (34.9 ± 0.6°C) on four occasions: 1) 2 days before blood donation (C(ON) ), 2) 2 hours after donation (D(ON) ), 3) 2 days after donation (2 D(AYS) ), and 4) 7 days after donation (7 D(AYS) ). RESULTS: Two-thirds of the blood volume withdrawn was endogenously restored before exercise in the D(ON) trial (p < 0.05). D(ON) started with increased preexercise rectal temperature (T(RE) ; 0.42 ± 0.1°C above C(ON) ; p < 0.05), which resulted in high levels of hyperthermia (i.e., 39.0 ± 0.2°C) after 1 hour of exercise. Skin temperature (34.5 ± 0.1°C) and sweat rate (1.15 ± 0.1 L/h) were not affected by D(ON) . However, D(ON) lowered the skin blood flow : T(RE) relationship and elevated heart rate (HR) above C(ON) (12 ± 4 beats/min; p < 0.05) maintaining cardiac output. After 2 D(AYS) , T(RE) and HR were restored to C(ON) levels while cardiac output increased above C(ON) (6%; p < 0.05) in association with reduced hemoglobin concentration (i.e., peak hemodilution). CONCLUSION: A blood bank donation increases preexercise T(RE) . Subsequent exercise in a hot environment results in high levels of hyperthermia and HR. These thermoregulatory and cardiovascular perturbations observed during exercise disappear 2 days after donation.
Ricardo Mora-Rodriguez; Roberto Aguado-Jimenez; Juan Del Coso; Emma Estevez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-27
Journal Detail:
Title:  Transfusion     Volume:  -     ISSN:  1537-2995     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 American Association of Blood Banks.
From the Exercise Physiology Laboratory at Toledo, University of Castilla-La Mancha, Toledo, Spain; Public University of Navarra, Navarra, Spain; Universidad Camilo José Cela, Madrid, Spain; and Baker IDI Heart & Diabetes Research Institute, Victoria, Australia.
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