Document Detail

staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice.
MedLine Citation:
PMID:  9520475     Owner:  NLM     Status:  MEDLINE    
Retinoid-related orphan receptor alpha (RORalpha) is a member of the nuclear receptor superfamily. To study its physiological role we generated null-mutant mice by targeted insertion of a lacZ reporter gene encoding the enzyme beta-galactosidase. In heterozygous RORalpha+/- mice we found beta-galactosidase activity, indicative of RORalpha protein expression, confined to the central nervous system, skin and testis. In the central nervous system, the RORalpha gene is expressed in cerebellar Purkinje cells, the thalamus, the suprachiasmatic nuclei, and retinal ganglion cells. In skin, RORalpha is strongly expressed in the hair follicle, the epidermis, and the sebaceous gland. Finally, the peritubular cells of the testis and the epithelial cells of the epididymis also strongly express RORalpha. Recently, it was reported that the ataxic mouse mutant staggerer (sg/sg) is caused by a deletion in the RORalpha gene. The analysis of the cerebellar and the behavioral phenotype of homozygous RORalpha-/- mice proves identity to sg/sg mice. Although the absence of RORalpha causes dramatic developmental effects in the cerebellum, it has no apparent morphological effect on thalamus, hypothalamus, and retina. Similarly, testis and skin of RORalpha-/- mice display a normal phenotype. However, the pelage hair of both sg/sg and RORalpha-/- is significantly less dense and when shaved shows reluctance to regrow.
M Steinmayr; E André; F Conquet; L Rondi-Reig; N Delhaye-Bouchaud; N Auclair; H Daniel; F Crépel; J Mariani; C Sotelo; M Becker-André
Related Documents :
20331445 - Tamoxifen-loaded liposomal topical formulation arrests hair growth in mice.
15329475 - Xenografting of bovine secondary follicles into ovariectomized female severe combined i...
3481965 - Lingual changes in ageing mice by light- and scanning electron-microscopy.
17764695 - Increased rate of hair regrowth in mice with constitutive overexpression of del1.
17591895 - The role of soluble tnf receptors for tnf-alpha in uveitis.
19683335 - Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in mn9d cells.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  95     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-01     Completed Date:  1998-05-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3960-5     Citation Subset:  IM    
Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S.A., 4, chemin des Aulx, 1228 Plan-les-Ouates, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Behavior, Animal / physiology
Cerebellum / physiology*
Gene Expression Regulation*
Mice, Mutant Strains
Nerve Tissue Proteins / deficiency,  genetics*
Nuclear Receptor Subfamily 1, Group F, Member 1
Organ Specificity
Receptors, Cytoplasmic and Nuclear / deficiency,  genetics*
Trans-Activators / deficiency,  genetics*
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Nuclear Receptor Subfamily 1, Group F, Member 1; 0/Receptors, Cytoplasmic and Nuclear; 0/Trans-Activators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recombinant viruses expressing a human malaria antigen can elicit potentially protective immune CD8+...
Next Document:  Neuronal polarity: essential role of protein-lipid complexes in axonal sorting.