Document Detail


A stage specific approach to tumor surveillance after radical cystectomy for transitional cell carcinoma of the bladder.
MedLine Citation:
PMID:  10458349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Surveillance protocols after radical surgery for genitourinary tumors typically do not consider that the risk of recurrence is stage dependent. We describe the development of a stage specific protocol for monitoring patients with transitional cell carcinoma for tumor recurrence and conduit complications after radical cystectomy. MATERIALS AND METHODS: The records of 382 patients with transitional cell carcinoma who underwent cystectomy in 1986 to 1994 were reviewed for the dates and presenting symptoms of local and distant recurrences, and the results of radiological imaging studies and liver function tests. Based on the division of patients into pathological stages of pT1, pT2 and pT3 groups, we developed a new transitional cell carcinoma surveillance protocol. RESULTS: Of 97 patients with transitional cell carcinoma metastases 72 (74%) were asymptomatic, including 43 with metastases detected by routine chest x-rays (30) or blood tests (13). Surveillance computerized tomography identified isolated asymptomatic intra-abdominal metastases in 10 patients (10%), of whom 90% had pT3 disease. Based on these results we recommend a stage specific surveillance protocol for pT1--annual history, physical examination, chest x-ray and laboratory studies, pT2-same studies at 6, 12, 18, 24, 30, 36, 48 and 60 months after cystectomy, and pT3-same studies at 3, 6, 12, 18, 24, 30, 36, 48 and 60 months plus computerized tomography at 6, 12 and 24 months after cystectomy. A radiographic study of the upper tract should be performed in all patients every 1 to 2 years to evaluate for recurrences and complications of the ileoureteral anastomosis. CONCLUSIONS: A stage driven surveillance strategy for monitoring patients after radical cystectomy can reduce costly imaging studies while efficiently detecting recurrences and complications.
Authors:
J W Slaton; D A Swanson; H B Grossman; C P Dinney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  162     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-23     Completed Date:  1999-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  710-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Urology, University of Texas M.D. Anderson Cancer Center, Houston, USA.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Transitional Cell / pathology*,  secondary,  surgery*
Clinical Protocols
Cystectomy*
Follow-Up Studies
Humans
Neoplasm Recurrence, Local / epidemiology*
Neoplasm Staging
Population Surveillance
Retrospective Studies
Time Factors
Ureteral Neoplasms / secondary*
Urethral Neoplasms / secondary*
Urinary Bladder Neoplasms / pathology*,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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