Document Detail

A stable model of respiratory distress by small injections of oleic acid in pigs.
MedLine Citation:
PMID:  8708172     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Development of a stable model of respiratory distress in pigs with oleic acid, fulfilling clinical criteria of the adult respiratory distress syndrome (ARDS). DESIGN: Eight pigs (9.1 +/- 0.7 kg) were anesthetized with pentobarbital, paralyzed with tubocurarine and mechanically ventilated with an FIO2 of 0.6, an I:E ratio of 2:3 and a PEEP of 0.2 kPa. Oleic acid (dissolved 1:1 in 96% alcohol) was administered in a series of multiple injections of 0.1 ml until PaO2 was lower than 8 kPa. MEASUREMENTS AND RESULTS: Careful titration of the oleic acid injections on guidance of the PaO2 established a reproducible respiratory distress (PaO2 = 7.3 +/- 0.8 kPa), in which gas exchange and hemodynamic variables were stable for at least 4 h. The number of oleic acid injections (22 +/- 11, mean and SD) varied between the animals. CONCLUSIONS: With the use of multiple injections of oleic acid, a stable model of early respiratory distress in pigs can be achieved, in spite of individual differences in sensitivity. Such a stable model allows for a diversity of studies on early respiratory distress.
H P Grotjohan; R M van der Heijde; J R Jansen; C A Wagenvoort; A Versprille
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  22     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-09     Completed Date:  1996-09-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  336-44     Citation Subset:  IM    
Department of Puimonary Diseases, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Blood Gas Analysis
Disease Models, Animal*
Hemodynamics / physiology
Lung Volume Measurements
Oleic Acid
Oleic Acids / administration & dosage*
Pulmonary Gas Exchange
Respiratory Distress Syndrome, Adult / blood,  chemically induced*,  physiopathology
Reg. No./Substance:
0/Oleic Acids; 112-80-1/Oleic Acid; 9004-54-0/Dextrans

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